3ink

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[[Image:3ink.png|left|200px]]
 
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{{STRUCTURE_3ink| PDB=3ink | SCENE= }}
{{STRUCTURE_3ink| PDB=3ink | SCENE= }}
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===UNRAVELING THE STRUCTURE OF INTERLEUKIN-2: REPLY===
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===UNRAVELING THE STRUCTURE OF INTERLEUKIN-2: REPLY===
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==Disease==
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[[http://www.uniprot.org/uniprot/IL2_HUMAN IL2_HUMAN]] Note=A chromosomal aberration involving IL2 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with involves TNFRSF17.
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==Function==
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[[http://www.uniprot.org/uniprot/IL2_HUMAN IL2_HUMAN]] Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells.
==About this Structure==
==About this Structure==
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==Reference==
==Reference==
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<ref group="xtra">PMID:001631562</ref><ref group="xtra">PMID:009015358</ref><ref group="xtra">PMID:009237811</ref><references group="xtra"/>
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<ref group="xtra">PMID:001631562</ref><ref group="xtra">PMID:009015358</ref><ref group="xtra">PMID:009237811</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Brandhuber, B J.]]
[[Category: Brandhuber, B J.]]
[[Category: Mckay, D B.]]
[[Category: Mckay, D B.]]
[[Category: Cytokine]]
[[Category: Cytokine]]

Revision as of 06:01, 25 March 2013

Template:STRUCTURE 3ink

Contents

UNRAVELING THE STRUCTURE OF INTERLEUKIN-2: REPLY

Disease

[IL2_HUMAN] Note=A chromosomal aberration involving IL2 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with involves TNFRSF17.

Function

[IL2_HUMAN] Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells.

About this Structure

3ink is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

Reference

  • Bazan JF. Unraveling the structure of IL-2. Science. 1992 Jul 17;257(5068):410-3. PMID:1631562
  • Wang Y, Li L, Liu J, Wang Z, Jiang C, Liu X. The analgesic domain of IL-2. Biochem Biophys Res Commun. 1997 Jan 23;230(3):542-5. PMID:9015358 doi:10.1006/bbrc.1996.5961
  • Eckenberg R, Xu D, Moreau JL, Bossus M, Mazie JC, Tartar A, Liu XY, Alzari PM, Bertoglio J, Theze J. Analysis of human IL-2/IL-2 receptor beta chain interactions: monoclonal antibody H2-8 and new IL-2 mutants define the critical role of alpha helix-A of IL-2. Cytokine. 1997 Jul;9(7):488-98. PMID:9237811 doi:10.1006/cyto.1996.0192

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OCA

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