3ncl
From Proteopedia
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{{STRUCTURE_3ncl| PDB=3ncl | SCENE= }} | {{STRUCTURE_3ncl| PDB=3ncl | SCENE= }} | ||
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===Crystal Structure of MT-SP1 bound to Benzamidine Phosphonate Inhibitor=== | ===Crystal Structure of MT-SP1 bound to Benzamidine Phosphonate Inhibitor=== | ||
| + | {{ABSTRACT_PUBMED_21276938}} | ||
| + | ==Disease== | ||
| + | [[http://www.uniprot.org/uniprot/ST14_HUMAN ST14_HUMAN]] Defects in ST14 are a cause of ichthyosis autosomal recessive with hypotrichosis (ARIH) [MIM:[http://omim.org/entry/610765 610765]]. ARIH is a skin disorder characterized by congenital ichthyosis associated with the presence of less than the normal amount of hair.<ref>PMID:17273967</ref> | ||
| - | + | ==Function== | |
| - | + | [[http://www.uniprot.org/uniprot/ST14_HUMAN ST14_HUMAN]] Degrades extracellular matrix. Proposed to play a role in breast cancer invasion and metastasis. Exhibits trypsin-like activity as defined by cleavage of synthetic substrates with Arg or Lys as the P1 site. | |
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==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID: | + | <ref group="xtra">PMID:021276938</ref><references group="xtra"/><references/> |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Matriptase]] | [[Category: Matriptase]] | ||
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[[Category: Egea, P.]] | [[Category: Egea, P.]] | ||
[[Category: Ray, M.]] | [[Category: Ray, M.]] | ||
| + | [[Category: Benzamidine]] | ||
| + | [[Category: Hydrolase]] | ||
| + | [[Category: Phosphonate]] | ||
| + | [[Category: Proteinase-inhibitor complex]] | ||
| + | [[Category: Serine endopeptidase]] | ||
| + | [[Category: Serine proteinase]] | ||
Revision as of 06:07, 25 March 2013
Contents |
Crystal Structure of MT-SP1 bound to Benzamidine Phosphonate Inhibitor
Template:ABSTRACT PUBMED 21276938
Disease
[ST14_HUMAN] Defects in ST14 are a cause of ichthyosis autosomal recessive with hypotrichosis (ARIH) [MIM:610765]. ARIH is a skin disorder characterized by congenital ichthyosis associated with the presence of less than the normal amount of hair.[1]
Function
[ST14_HUMAN] Degrades extracellular matrix. Proposed to play a role in breast cancer invasion and metastasis. Exhibits trypsin-like activity as defined by cleavage of synthetic substrates with Arg or Lys as the P1 site.
About this Structure
3ncl is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Brown CM, Ray M, Eroy-Reveles AA, Egea P, Tajon C, Craik CS. Peptide length and leaving-group sterics influence potency of Peptide phosphonate protease inhibitors. Chem Biol. 2011 Jan 28;18(1):48-57. PMID:21276938 doi:10.1016/j.chembiol.2010.11.007
- ↑ Basel-Vanagaite L, Attia R, Ishida-Yamamoto A, Rainshtein L, Ben Amitai D, Lurie R, Pasmanik-Chor M, Indelman M, Zvulunov A, Saban S, Magal N, Sprecher E, Shohat M. Autosomal recessive ichthyosis with hypotrichosis caused by a mutation in ST14, encoding type II transmembrane serine protease matriptase. Am J Hum Genet. 2007 Mar;80(3):467-77. Epub 2007 Jan 23. PMID:17273967 doi:S0002-9297(07)60095-0
