2i96

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[[Image:2i96.png|left|200px]]
 
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{{STRUCTURE_2i96| PDB=2i96 | SCENE= }}
{{STRUCTURE_2i96| PDB=2i96 | SCENE= }}
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===Solution structure of the oxidized microsomal human cytochrome b5===
===Solution structure of the oxidized microsomal human cytochrome b5===
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==Disease==
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[[http://www.uniprot.org/uniprot/CYB5_HUMAN CYB5_HUMAN]] Defects in CYB5A are the cause of methemoglobinemia CYB5A-related (METHB-CYB5A) [MIM:[http://omim.org/entry/250790 250790]]. A form of methemoglobinemia, a hematologic disease characterized by the presence of excessive amounts of methemoglobin in blood cells, resulting in decreased oxygen carrying capacity of the blood, cyanosis and hypoxia.<ref>PMID:8168836</ref>
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==Function==
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[[http://www.uniprot.org/uniprot/CYB5_HUMAN CYB5_HUMAN]] Cytochrome b5 is a membrane bound hemoprotein which function as an electron carrier for several membrane bound oxygenases.
==About this Structure==
==About this Structure==
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==See Also==
==See Also==
*[[Cytochrome b5|Cytochrome b5]]
*[[Cytochrome b5|Cytochrome b5]]
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==Reference==
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<references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Heijenoort, C Van.]]
[[Category: Heijenoort, C Van.]]

Revision as of 06:12, 25 March 2013

Template:STRUCTURE 2i96

Contents

Solution structure of the oxidized microsomal human cytochrome b5

Disease

[CYB5_HUMAN] Defects in CYB5A are the cause of methemoglobinemia CYB5A-related (METHB-CYB5A) [MIM:250790]. A form of methemoglobinemia, a hematologic disease characterized by the presence of excessive amounts of methemoglobin in blood cells, resulting in decreased oxygen carrying capacity of the blood, cyanosis and hypoxia.[1]

Function

[CYB5_HUMAN] Cytochrome b5 is a membrane bound hemoprotein which function as an electron carrier for several membrane bound oxygenases.

About this Structure

2i96 is a 1 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA.

See Also

Reference

  1. Giordano SJ, Kaftory A, Steggles AW. A splicing mutation in the cytochrome b5 gene from a patient with congenital methemoglobinemia and pseudohermaphrodism. Hum Genet. 1994 May;93(5):568-70. PMID:8168836

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