1ugv

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[[Image:1ugv.png|left|200px]]
 
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{{STRUCTURE_1ugv| PDB=1ugv | SCENE= }}
{{STRUCTURE_1ugv| PDB=1ugv | SCENE= }}
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===Solution structure of the SH3 domain of human olygophrein-1 like protein (KIAA0621)===
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===Solution structure of the SH3 domain of human olygophrein-1 like protein (KIAA0621)===
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==Disease==
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[[http://www.uniprot.org/uniprot/RHG26_HUMAN RHG26_HUMAN]] Defects in ARHGAP26 are a cause of juvenile myelomonocytic leukemia (JMML) [MIM:[http://omim.org/entry/607785 607785]]. JMML is a pediatric myelodysplastic syndrome that constitutes approximately 30% of childhood cases of myelodysplastic syndrome (MDS) and 2% of leukemia. Chromosomal translocation t(5;11)(q31;q23) with MLL has been found in a JMML patient.
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==Function==
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[[http://www.uniprot.org/uniprot/RHG26_HUMAN RHG26_HUMAN]] GTPase-activating protein for RHOA and CDC42.
==About this Structure==
==About this Structure==

Revision as of 06:26, 25 March 2013

Template:STRUCTURE 1ugv

Contents

Solution structure of the SH3 domain of human olygophrein-1 like protein (KIAA0621)

Disease

[RHG26_HUMAN] Defects in ARHGAP26 are a cause of juvenile myelomonocytic leukemia (JMML) [MIM:607785]. JMML is a pediatric myelodysplastic syndrome that constitutes approximately 30% of childhood cases of myelodysplastic syndrome (MDS) and 2% of leukemia. Chromosomal translocation t(5;11)(q31;q23) with MLL has been found in a JMML patient.

Function

[RHG26_HUMAN] GTPase-activating protein for RHOA and CDC42.

About this Structure

1ugv is a 1 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA.

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OCA

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