2dc3
From Proteopedia
(New page: 200px<br /> <applet load="2dc3" size="450" color="white" frame="true" align="right" spinBox="true" caption="2dc3, resolution 1.68Å" /> '''Crystal structure o...) |
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| - | [[Image:2dc3.gif|left|200px]]<br /> | + | [[Image:2dc3.gif|left|200px]]<br /><applet load="2dc3" size="350" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="2dc3" size=" | + | |
caption="2dc3, resolution 1.68Å" /> | caption="2dc3, resolution 1.68Å" /> | ||
'''Crystal structure of human cytoglobin at 1.68 angstroms resolution'''<br /> | '''Crystal structure of human cytoglobin at 1.68 angstroms resolution'''<br /> | ||
==Overview== | ==Overview== | ||
| - | Cytoglobin (Cgb) is a recently discovered member of the vertebrate | + | Cytoglobin (Cgb) is a recently discovered member of the vertebrate haem-containing globin family. The structure of a new crystal form of wild-type human Cgb (space group C2) was determined at a resolution of 1.68 Angstrom. The results show the presence of an additional helix in the N-terminal residues (4-20) prior to the A helix and an ordered loop structure in the C-terminal region (168-188), while these extended peptides were invisible owing to disorder in the previously reported structures using a P3(2)21 crystal at a resolution of 2.4 Angstrom. A detailed comparison of the two crystal structures shows differences in the conformation of the residues (i.e. Arg84) in the haem environment owing to a different dimeric arrangement. |
==About this Structure== | ==About this Structure== | ||
| - | 2DC3 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with HEM and ACY as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http:// | + | 2DC3 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=HEM:'>HEM</scene> and <scene name='pdbligand=ACY:'>ACY</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DC3 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Kawada, N.]] | [[Category: Kawada, N.]] | ||
[[Category: Makino, M.]] | [[Category: Makino, M.]] | ||
| - | [[Category: RSGI, RIKEN | + | [[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]] |
[[Category: Sawai, H.]] | [[Category: Sawai, H.]] | ||
[[Category: Shiro, Y.]] | [[Category: Shiro, Y.]] | ||
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[[Category: structural genomics]] | [[Category: structural genomics]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:57:17 2008'' |
Revision as of 14:57, 21 February 2008
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Crystal structure of human cytoglobin at 1.68 angstroms resolution
Overview
Cytoglobin (Cgb) is a recently discovered member of the vertebrate haem-containing globin family. The structure of a new crystal form of wild-type human Cgb (space group C2) was determined at a resolution of 1.68 Angstrom. The results show the presence of an additional helix in the N-terminal residues (4-20) prior to the A helix and an ordered loop structure in the C-terminal region (168-188), while these extended peptides were invisible owing to disorder in the previously reported structures using a P3(2)21 crystal at a resolution of 2.4 Angstrom. A detailed comparison of the two crystal structures shows differences in the conformation of the residues (i.e. Arg84) in the haem environment owing to a different dimeric arrangement.
About this Structure
2DC3 is a Single protein structure of sequence from Homo sapiens with and as ligands. Full crystallographic information is available from OCA.
Reference
High-resolution structure of human cytoglobin: identification of extra N- and C-termini and a new dimerization mode., Makino M, Sugimoto H, Sawai H, Kawada N, Yoshizato K, Shiro Y, Acta Crystallogr D Biol Crystallogr. 2006 Jun;62(Pt 6):671-7. Epub 2006, May 12. PMID:16699195
Page seeded by OCA on Thu Feb 21 16:57:17 2008
Categories: Homo sapiens | Single protein | Kawada, N. | Makino, M. | RSGI, RIKEN Structural Genomics/Proteomics Initiative. | Sawai, H. | Shiro, Y. | Sugimoto, H. | Yoshizato, K. | ACY | HEM | Cytoglobin | Heme | Myoglobin | Oxygen storage | Oxygen transport | Riken structural genomics/proteomics initiative | Rsgi | Structural genomics
