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3mi2
From Proteopedia
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{{STRUCTURE_3mi2| PDB=3mi2 | SCENE= }} | {{STRUCTURE_3mi2| PDB=3mi2 | SCENE= }} | ||
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===Crystal structure of human orotidine-5'-monophosphate decarboxylase complexed with pyrazofurin monophosphate=== | ===Crystal structure of human orotidine-5'-monophosphate decarboxylase complexed with pyrazofurin monophosphate=== | ||
| + | {{ABSTRACT_PUBMED_20452222}} | ||
| + | ==Disease== | ||
| + | [[http://www.uniprot.org/uniprot/PYR5_HUMAN PYR5_HUMAN]] Defects in UMPS are the cause of orotic aciduria type 1 (ORAC1) [MIM:[http://omim.org/entry/258900 258900]]. A disorder of pyrimidine metabolism resulting in megaloblastic anemia and orotic acid crystalluria that is frequently associated with some degree of physical and mental retardation. A minority of cases have additional features, particularly congenital malformations and immune deficiencies.<ref>PMID:9042911</ref> | ||
| - | + | ==About this Structure== | |
| - | + | [[3mi2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MI2 OCA]. | |
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| - | == | + | ==See Also== |
| - | + | *[[Phosphoribosyltransferase|Phosphoribosyltransferase]] | |
| + | *[[Uridine 5'-monophosphate synthase|Uridine 5'-monophosphate synthase]] | ||
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID: | + | <ref group="xtra">PMID:020452222</ref><references group="xtra"/><references/> |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Orotidine-5'-phosphate decarboxylase]] | [[Category: Orotidine-5'-phosphate decarboxylase]] | ||
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[[Category: Pyrazofurin monophosphate]] | [[Category: Pyrazofurin monophosphate]] | ||
[[Category: Ump synthase]] | [[Category: Ump synthase]] | ||
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| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 16 08:14:36 2010'' | ||
Revision as of 06:56, 25 March 2013
Contents |
Crystal structure of human orotidine-5'-monophosphate decarboxylase complexed with pyrazofurin monophosphate
Template:ABSTRACT PUBMED 20452222
Disease
[PYR5_HUMAN] Defects in UMPS are the cause of orotic aciduria type 1 (ORAC1) [MIM:258900]. A disorder of pyrimidine metabolism resulting in megaloblastic anemia and orotic acid crystalluria that is frequently associated with some degree of physical and mental retardation. A minority of cases have additional features, particularly congenital malformations and immune deficiencies.[1]
About this Structure
3mi2 is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
See Also
Reference
- Meza-Avina ME, Wei L, Liu Y, Poduch E, Bello AM, Mishra RK, Pai EF, Kotra LP. Structural determinants for the inhibitory ligands of orotidine-5'-monophosphate decarboxylase. Bioorg Med Chem. 2010 Jun 1;18(11):4032-41. Epub 2010 Apr 9. PMID:20452222 doi:10.1016/j.bmc.2010.04.017
