2dnf

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[[Image:2dnf.png|left|200px]]
 
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{{STRUCTURE_2dnf| PDB=2dnf | SCENE= }}
{{STRUCTURE_2dnf| PDB=2dnf | SCENE= }}
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===Solution structure of RSGI RUH-062, a DCX domain from human===
===Solution structure of RSGI RUH-062, a DCX domain from human===
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==Disease==
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[[http://www.uniprot.org/uniprot/DCDC2_HUMAN DCDC2_HUMAN]] Defects in DCDC2 may be a cause of susceptibility to dyslexia type 2 (DYX2) [MIM:[http://omim.org/entry/600202 600202]]; also known as specific reading disability type 2. Dyslexia is a relatively common, complex cognitive disorder that affects 5% to 10% of school-aged children. The disorder is characterized by an impairment of reading performance despite adequate motivational, educational and intellectual opportunities and in the absence of sensory or neurological disability.<ref>PMID:16278297</ref>
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==Function==
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[[http://www.uniprot.org/uniprot/DCDC2_HUMAN DCDC2_HUMAN]] May be involved in neuronal migration during development of the cerebral neocortex (By similarity).
==About this Structure==
==About this Structure==
[[2dnf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DNF OCA].
[[2dnf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DNF OCA].
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==Reference==
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<references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Hayashi, F.]]
[[Category: Hayashi, F.]]

Revision as of 06:56, 25 March 2013

Template:STRUCTURE 2dnf

Contents

Solution structure of RSGI RUH-062, a DCX domain from human

Disease

[DCDC2_HUMAN] Defects in DCDC2 may be a cause of susceptibility to dyslexia type 2 (DYX2) [MIM:600202]; also known as specific reading disability type 2. Dyslexia is a relatively common, complex cognitive disorder that affects 5% to 10% of school-aged children. The disorder is characterized by an impairment of reading performance despite adequate motivational, educational and intellectual opportunities and in the absence of sensory or neurological disability.[1]

Function

[DCDC2_HUMAN] May be involved in neuronal migration during development of the cerebral neocortex (By similarity).

About this Structure

2dnf is a 1 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

  1. ↑ Meng H, Smith SD, Hager K, Held M, Liu J, Olson RK, Pennington BF, DeFries JC, Gelernter J, O'Reilly-Pol T, Somlo S, Skudlarski P, Shaywitz SE, Shaywitz BA, Marchione K, Wang Y, Paramasivam M, LoTurco JJ, Page GP, Gruen JR. DCDC2 is associated with reading disability and modulates neuronal development in the brain. Proc Natl Acad Sci U S A. 2005 Nov 22;102(47):17053-8. Epub 2005 Nov 8. PMID:16278297 doi:10.1073/pnas.0508591102

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