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2ery

From Proteopedia

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[[Image:2ery.png|left|200px]]
 
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{{STRUCTURE_2ery| PDB=2ery | SCENE= }}
{{STRUCTURE_2ery| PDB=2ery | SCENE= }}
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===The crystal structure of the Ras related protein RRas2 (RRAS2) in the GDP bound state===
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===The crystal structure of the Ras related protein RRas2 (RRAS2) in the GDP bound state===
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==Disease==
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[[http://www.uniprot.org/uniprot/RRAS2_HUMAN RRAS2_HUMAN]] Defects in RRAS2 are a cause of susceptibility to ovarian cancer (OC) [MIM:[http://omim.org/entry/167000 167000]]. The term ovarian cancer defines common malignancies originating from ovarian tissue. Although many histologic types of ovarian tumors have been described, epithelial ovarian carcinoma is the most common form. Ovarian cancers are often asymptomatic and the recognized signs and symptoms, even of late-stage disease, are vague. Consequently, most patients are diagnosed with advanced disease.
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==Function==
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[[http://www.uniprot.org/uniprot/RRAS2_HUMAN RRAS2_HUMAN]] It is a plasma membrane-associated GTP-binding protein with GTPase activity. Might transduce growth inhibitory signals across the cell membrane, exerting its effect through an effector shared with the Ras proteins but in an antagonistic fashion.
==About this Structure==
==About this Structure==

Revision as of 07:04, 25 March 2013

Template:STRUCTURE 2ery

Contents

The crystal structure of the Ras related protein RRas2 (RRAS2) in the GDP bound state

Disease

[RRAS2_HUMAN] Defects in RRAS2 are a cause of susceptibility to ovarian cancer (OC) [MIM:167000]. The term ovarian cancer defines common malignancies originating from ovarian tissue. Although many histologic types of ovarian tumors have been described, epithelial ovarian carcinoma is the most common form. Ovarian cancers are often asymptomatic and the recognized signs and symptoms, even of late-stage disease, are vague. Consequently, most patients are diagnosed with advanced disease.

Function

[RRAS2_HUMAN] It is a plasma membrane-associated GTP-binding protein with GTPase activity. Might transduce growth inhibitory signals across the cell membrane, exerting its effect through an effector shared with the Ras proteins but in an antagonistic fashion.

About this Structure

2ery is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

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OCA

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