4deq

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[[Image:4deq.png|left|200px]]
 
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{{STRUCTURE_4deq| PDB=4deq | SCENE= }}
{{STRUCTURE_4deq| PDB=4deq | SCENE= }}
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===Structure of the Neuropilin-1/VEGF-A complex===
===Structure of the Neuropilin-1/VEGF-A complex===
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{{ABSTRACT_PUBMED_22318724}}
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{{ABSTRACT_PUBMED_22318724}}
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==Function==
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[[http://www.uniprot.org/uniprot/NRP1_HUMAN NRP1_HUMAN]] The membrane-bound isoform 1 is a receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. It binds to semaphorin 3A, The PLGF-2 isoform of PGF, The VEGF-165 isoform of VEGF and VEGF-B. Coexpression with KDR results in increased VEGF-165 binding to KDR as well as increased chemotaxis. It may regulate VEGF-induced angiogenesis. The soluble isoform 2 binds VEGF-165 and appears to inhibit its binding to cells. It may also induce apoptosis by sequestering VEGF-165. May bind as well various members of the semaphorin family. Its expression has an averse effect on blood vessel number and integrity.
==About this Structure==
==About this Structure==
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==Reference==
==Reference==
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<ref group="xtra">PMID:022318724</ref><references group="xtra"/>
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<ref group="xtra">PMID:022318724</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Kooi, C W.Vander.]]
[[Category: Kooi, C W.Vander.]]

Revision as of 07:12, 25 March 2013

Template:STRUCTURE 4deq

Contents

Structure of the Neuropilin-1/VEGF-A complex

Template:ABSTRACT PUBMED 22318724

Function

[NRP1_HUMAN] The membrane-bound isoform 1 is a receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. It binds to semaphorin 3A, The PLGF-2 isoform of PGF, The VEGF-165 isoform of VEGF and VEGF-B. Coexpression with KDR results in increased VEGF-165 binding to KDR as well as increased chemotaxis. It may regulate VEGF-induced angiogenesis. The soluble isoform 2 binds VEGF-165 and appears to inhibit its binding to cells. It may also induce apoptosis by sequestering VEGF-165. May bind as well various members of the semaphorin family. Its expression has an averse effect on blood vessel number and integrity.

About this Structure

4deq is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Parker MW, Xu P, Li X, Vander Kooi CW. Structural basis for the selective vascular endothelial growth factor-A (VEGF-A) binding to neuropilin-1. J Biol Chem. 2012 Feb 7. PMID:22318724 doi:10.1074/jbc.M111.331140

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OCA

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