2dde
From Proteopedia
(New page: 200px<br /><applet load="2dde" size="450" color="white" frame="true" align="right" spinBox="true" caption="2dde" /> '''Structure of cinnamycin complexed with lysop...) |
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| - | [[Image:2dde.gif|left|200px]]<br /><applet load="2dde" size=" | + | [[Image:2dde.gif|left|200px]]<br /><applet load="2dde" size="350" color="white" frame="true" align="right" spinBox="true" |
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'''Structure of cinnamycin complexed with lysophosphatidylethanolamine'''<br /> | '''Structure of cinnamycin complexed with lysophosphatidylethanolamine'''<br /> | ||
==Overview== | ==Overview== | ||
| - | The three-dimensional structure of a complex of cinnamycin, a 19-amino | + | The three-dimensional structure of a complex of cinnamycin, a 19-amino acid residue immunopotentiator peptide, and lysophosphatidylethanolamine was determined by 1H-NMR. The complex was cylindrical in shape, 11 A in diameter and 26 A in length, excluding the acyl chain of the phospholipid. The peptide had a hydrophobic pocket surrounded by residues Phe-7 through Ala(S)-14 to bind to the head group of the ligand. Fitting of the head group to the hydrophobic pocket was so good that other than a glycerophosphoethanolamine head group would be unable to fit the pocket. The goodness of the fitting is compatible with the strict specificity of ligand binding of the peptide. |
==About this Structure== | ==About this Structure== | ||
| - | 2DDE is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Streptomyces_griseoverticillatus Streptomyces griseoverticillatus] with LSP as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | + | 2DDE is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Streptomyces_griseoverticillatus Streptomyces griseoverticillatus] with <scene name='pdbligand=LSP:'>LSP</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DDE OCA]. |
==Reference== | ==Reference== | ||
| - | Structure determination of an immunopotentiator peptide, cinnamycin, complexed with lysophosphatidylethanolamine by 1H-NMR1., Hosoda K, Ohya M, Kohno T, Maeda T, Endo S, Wakamatsu K, J Biochem | + | Structure determination of an immunopotentiator peptide, cinnamycin, complexed with lysophosphatidylethanolamine by 1H-NMR1., Hosoda K, Ohya M, Kohno T, Maeda T, Endo S, Wakamatsu K, J Biochem. 1996 Feb;119(2):226-30. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=8882709 8882709] |
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Streptomyces griseoverticillatus]] | [[Category: Streptomyces griseoverticillatus]] | ||
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[[Category: phosphatidylethanolamine]] | [[Category: phosphatidylethanolamine]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:57:39 2008'' |
Revision as of 14:57, 21 February 2008
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Structure of cinnamycin complexed with lysophosphatidylethanolamine
Overview
The three-dimensional structure of a complex of cinnamycin, a 19-amino acid residue immunopotentiator peptide, and lysophosphatidylethanolamine was determined by 1H-NMR. The complex was cylindrical in shape, 11 A in diameter and 26 A in length, excluding the acyl chain of the phospholipid. The peptide had a hydrophobic pocket surrounded by residues Phe-7 through Ala(S)-14 to bind to the head group of the ligand. Fitting of the head group to the hydrophobic pocket was so good that other than a glycerophosphoethanolamine head group would be unable to fit the pocket. The goodness of the fitting is compatible with the strict specificity of ligand binding of the peptide.
About this Structure
2DDE is a Single protein structure of sequence from Streptomyces griseoverticillatus with as ligand. Full crystallographic information is available from OCA.
Reference
Structure determination of an immunopotentiator peptide, cinnamycin, complexed with lysophosphatidylethanolamine by 1H-NMR1., Hosoda K, Ohya M, Kohno T, Maeda T, Endo S, Wakamatsu K, J Biochem. 1996 Feb;119(2):226-30. PMID:8882709
Page seeded by OCA on Thu Feb 21 16:57:39 2008
