1jyd
From Proteopedia
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| - | [[Image:1jyd.png|left|200px]] | ||
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{{STRUCTURE_1jyd| PDB=1jyd | SCENE= }} | {{STRUCTURE_1jyd| PDB=1jyd | SCENE= }} | ||
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===Crystal Structure of Recombinant Human Serum Retinol-Binding Protein at 1.7 A Resolution=== | ===Crystal Structure of Recombinant Human Serum Retinol-Binding Protein at 1.7 A Resolution=== | ||
| + | {{ABSTRACT_PUBMED_11604536}} | ||
| - | + | ==Disease== | |
| + | [[http://www.uniprot.org/uniprot/RET4_HUMAN RET4_HUMAN]] Defects in RBP4 are a cause of retinol-binding protein deficiency (RBP deficiency) [MIM:[http://omim.org/entry/180250 180250]]. This condition causes night vision problems. It produces a typical 'fundus xerophthalmicus', featuring a progressed atrophy of the retinal pigment epithelium. | ||
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| + | ==Function== | ||
| + | [[http://www.uniprot.org/uniprot/RET4_HUMAN RET4_HUMAN]] Delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin, this prevents its loss by filtration through the kidney glomeruli. | ||
==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID:011604536</ref><references group="xtra"/> | + | <ref group="xtra">PMID:011604536</ref><references group="xtra"/><references/> |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Acharya, K R.]] | [[Category: Acharya, K R.]] | ||
Revision as of 07:23, 25 March 2013
Contents |
Crystal Structure of Recombinant Human Serum Retinol-Binding Protein at 1.7 A Resolution
Template:ABSTRACT PUBMED 11604536
Disease
[RET4_HUMAN] Defects in RBP4 are a cause of retinol-binding protein deficiency (RBP deficiency) [MIM:180250]. This condition causes night vision problems. It produces a typical 'fundus xerophthalmicus', featuring a progressed atrophy of the retinal pigment epithelium.
Function
[RET4_HUMAN] Delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin, this prevents its loss by filtration through the kidney glomeruli.
About this Structure
1jyd is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
See Also
Reference
- Greene LH, Chrysina ED, Irons LI, Papageorgiou AC, Acharya KR, Brew K. Role of conserved residues in structure and stability: tryptophans of human serum retinol-binding protein, a model for the lipocalin superfamily. Protein Sci. 2001 Nov;10(11):2301-16. PMID:11604536
