Sandbox Reserved 595
From Proteopedia
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I would like the page to have a table of contents and the following main sections: Background, Structure (with a jmol image area), Function, Clinical Relevance, and References. | I would like the page to have a table of contents and the following main sections: Background, Structure (with a jmol image area), Function, Clinical Relevance, and References. | ||
| - | + | =Background= | |
Apolipoprotein E is a member of the apolipoprotein family. This soluble apolipoprotein is produced primarily in the liver and brain; and it is located principally in the plasma and in the central nervous system (CNS) (AA). The systemic transport of cholesterol and other lipids is this protein's principle role in the body (W). One minor function it may exhibit is that of immune regulation (W). Particular isoforms, ε2 and ε4 implicated in hyperlipoproteinemia (HLP III) and late onset Alzheimer's disease (LOAD). ApoE may also play a role in synaptic integrity and plasticity (R). | Apolipoprotein E is a member of the apolipoprotein family. This soluble apolipoprotein is produced primarily in the liver and brain; and it is located principally in the plasma and in the central nervous system (CNS) (AA). The systemic transport of cholesterol and other lipids is this protein's principle role in the body (W). One minor function it may exhibit is that of immune regulation (W). Particular isoforms, ε2 and ε4 implicated in hyperlipoproteinemia (HLP III) and late onset Alzheimer's disease (LOAD). ApoE may also play a role in synaptic integrity and plasticity (R). | ||
| - | === | + | =Structure= |
| + | ==Primary Structural Features== | ||
| + | Apolipoprotein E is a polymorphic glycoprotein that consists of 299 amino acids (A,F). It has a molecular weight of 34kDa (G). The primary structure for ApoE is rich in the amino acid argine (W). | ||
| + | ==Secondary Structural Features== | ||
Revision as of 00:44, 27 March 2013
| This Sandbox is Reserved from Feb 1, 2013, through May 10, 2013 for use in the course "Biochemistry" taught by Irma Santoro at the Reinhardt University. This reservation includes Sandbox Reserved 591 through Sandbox Reserved 599. |
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I would like the page to have a table of contents and the following main sections: Background, Structure (with a jmol image area), Function, Clinical Relevance, and References.
Contents |
Background
Apolipoprotein E is a member of the apolipoprotein family. This soluble apolipoprotein is produced primarily in the liver and brain; and it is located principally in the plasma and in the central nervous system (CNS) (AA). The systemic transport of cholesterol and other lipids is this protein's principle role in the body (W). One minor function it may exhibit is that of immune regulation (W). Particular isoforms, ε2 and ε4 implicated in hyperlipoproteinemia (HLP III) and late onset Alzheimer's disease (LOAD). ApoE may also play a role in synaptic integrity and plasticity (R).
Structure
Primary Structural Features
Apolipoprotein E is a polymorphic glycoprotein that consists of 299 amino acids (A,F). It has a molecular weight of 34kDa (G). The primary structure for ApoE is rich in the amino acid argine (W).
