This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
3hb8
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | [[Image:3hb8.png|left|200px]] | ||
| - | |||
{{STRUCTURE_3hb8| PDB=3hb8 | SCENE= }} | {{STRUCTURE_3hb8| PDB=3hb8 | SCENE= }} | ||
| - | |||
===Structures of Thymidylate Synthase R163K with Substrates and Inhibitors Show Subunit Asymmetry=== | ===Structures of Thymidylate Synthase R163K with Substrates and Inhibitors Show Subunit Asymmetry=== | ||
| + | {{ABSTRACT_PUBMED_21206062}} | ||
| + | ==Function== | ||
| + | [[http://www.uniprot.org/uniprot/TYSY_HUMAN TYSY_HUMAN]] Contributes to the de novo mitochondrial thymidylate biosynthesis pathway.<ref>PMID:21876188</ref> | ||
==About this Structure== | ==About this Structure== | ||
| Line 11: | Line 11: | ||
==See Also== | ==See Also== | ||
*[[Thymidylate synthase|Thymidylate synthase]] | *[[Thymidylate synthase|Thymidylate synthase]] | ||
| + | |||
| + | ==Reference== | ||
| + | <ref group="xtra">PMID:021206062</ref><references group="xtra"/><references/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Thymidylate synthase]] | [[Category: Thymidylate synthase]] | ||
Revision as of 07:31, 27 March 2013
Contents |
Structures of Thymidylate Synthase R163K with Substrates and Inhibitors Show Subunit Asymmetry
Template:ABSTRACT PUBMED 21206062
Function
[TYSY_HUMAN] Contributes to the de novo mitochondrial thymidylate biosynthesis pathway.[1]
About this Structure
3hb8 is a 5 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
See Also
Reference
- Gibson LM, Celeste LR, Lovelace LL, Lebioda L. Structures of human thymidylate synthase R163K with dUMP, FdUMP and glutathione show asymmetric ligand binding. Acta Crystallogr D Biol Crystallogr. 2011 Jan;67(Pt 1):60-6. Epub 2010 Dec 16. PMID:21206062 doi:10.1107/S0907444910044732
- ↑ Anderson DD, Quintero CM, Stover PJ. Identification of a de novo thymidylate biosynthesis pathway in mammalian mitochondria. Proc Natl Acad Sci U S A. 2011 Sep 13;108(37):15163-8. doi:, 10.1073/pnas.1103623108. Epub 2011 Aug 26. PMID:21876188 doi:10.1073/pnas.1103623108
