3hb8
From Proteopedia
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{{STRUCTURE_3hb8| PDB=3hb8 | SCENE= }} | {{STRUCTURE_3hb8| PDB=3hb8 | SCENE= }} | ||
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===Structures of Thymidylate Synthase R163K with Substrates and Inhibitors Show Subunit Asymmetry=== | ===Structures of Thymidylate Synthase R163K with Substrates and Inhibitors Show Subunit Asymmetry=== | ||
| + | {{ABSTRACT_PUBMED_21206062}} | ||
| + | ==Function== | ||
| + | [[http://www.uniprot.org/uniprot/TYSY_HUMAN TYSY_HUMAN]] Contributes to the de novo mitochondrial thymidylate biosynthesis pathway.<ref>PMID:21876188</ref> | ||
==About this Structure== | ==About this Structure== | ||
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==See Also== | ==See Also== | ||
*[[Thymidylate synthase|Thymidylate synthase]] | *[[Thymidylate synthase|Thymidylate synthase]] | ||
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| + | ==Reference== | ||
| + | <ref group="xtra">PMID:021206062</ref><references group="xtra"/><references/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Thymidylate synthase]] | [[Category: Thymidylate synthase]] | ||
Revision as of 07:31, 27 March 2013
Contents |
Structures of Thymidylate Synthase R163K with Substrates and Inhibitors Show Subunit Asymmetry
Template:ABSTRACT PUBMED 21206062
Function
[TYSY_HUMAN] Contributes to the de novo mitochondrial thymidylate biosynthesis pathway.[1]
About this Structure
3hb8 is a 5 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
See Also
Reference
- Gibson LM, Celeste LR, Lovelace LL, Lebioda L. Structures of human thymidylate synthase R163K with dUMP, FdUMP and glutathione show asymmetric ligand binding. Acta Crystallogr D Biol Crystallogr. 2011 Jan;67(Pt 1):60-6. Epub 2010 Dec 16. PMID:21206062 doi:10.1107/S0907444910044732
- ↑ Anderson DD, Quintero CM, Stover PJ. Identification of a de novo thymidylate biosynthesis pathway in mammalian mitochondria. Proc Natl Acad Sci U S A. 2011 Sep 13;108(37):15163-8. doi:, 10.1073/pnas.1103623108. Epub 2011 Aug 26. PMID:21876188 doi:10.1073/pnas.1103623108
