2deb
From Proteopedia
(Difference between revisions)
(New page: 200px<br /><applet load="2deb" size="450" color="white" frame="true" align="right" spinBox="true" caption="2deb, resolution 1.60Å" /> '''Crystal structure of...) |
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| - | [[Image:2deb.jpg|left|200px]]<br /><applet load="2deb" size=" | + | [[Image:2deb.jpg|left|200px]]<br /><applet load="2deb" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="2deb, resolution 1.60Å" /> | caption="2deb, resolution 1.60Å" /> | ||
'''Crystal structure of rat carnitine palmitoyltransferase 2 in space group C2221'''<br /> | '''Crystal structure of rat carnitine palmitoyltransferase 2 in space group C2221'''<br /> | ||
==Overview== | ==Overview== | ||
| - | Carnitine palmitoyltransferases (CPTs) are part of the enzymatic system | + | Carnitine palmitoyltransferases (CPTs) are part of the enzymatic system that imports fatty acids into mitochondria. The crystal structure of rat CPT-2 by Rufer et al. (2006) (this issue of Structure) reveals a Y-shaped tunnel for binding the CoA and acyl-carnitine substrates and a hydrophobic insert mediating membrane association. |
==About this Structure== | ==About this Structure== | ||
| - | 2DEB is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] with BOG, COA and PLM as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Carnitine_O-palmitoyltransferase Carnitine O-palmitoyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.21 2.3.1.21] Full crystallographic information is available from [http:// | + | 2DEB is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] with <scene name='pdbligand=BOG:'>BOG</scene>, <scene name='pdbligand=COA:'>COA</scene> and <scene name='pdbligand=PLM:'>PLM</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Carnitine_O-palmitoyltransferase Carnitine O-palmitoyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.21 2.3.1.21] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DEB OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Rattus norvegicus]] | [[Category: Rattus norvegicus]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: Banner, D | + | [[Category: Banner, D W.]] |
[[Category: Benz, J.]] | [[Category: Benz, J.]] | ||
[[Category: Chomienne, O.]] | [[Category: Chomienne, O.]] | ||
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[[Category: Hennig, M.]] | [[Category: Hennig, M.]] | ||
[[Category: Mueller, F.]] | [[Category: Mueller, F.]] | ||
| - | [[Category: Roo, E | + | [[Category: Roo, E De.]] |
| - | [[Category: Rufer, A | + | [[Category: Rufer, A C.]] |
[[Category: Stihle, M.]] | [[Category: Stihle, M.]] | ||
[[Category: Thoma, R.]] | [[Category: Thoma, R.]] | ||
| Line 29: | Line 29: | ||
[[Category: central six-stranded beta-sheet]] | [[Category: central six-stranded beta-sheet]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:57:58 2008'' |
Revision as of 14:57, 21 February 2008
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Crystal structure of rat carnitine palmitoyltransferase 2 in space group C2221
Overview
Carnitine palmitoyltransferases (CPTs) are part of the enzymatic system that imports fatty acids into mitochondria. The crystal structure of rat CPT-2 by Rufer et al. (2006) (this issue of Structure) reveals a Y-shaped tunnel for binding the CoA and acyl-carnitine substrates and a hydrophobic insert mediating membrane association.
About this Structure
2DEB is a Single protein structure of sequence from Rattus norvegicus with , and as ligands. Active as Carnitine O-palmitoyltransferase, with EC number 2.3.1.21 Full crystallographic information is available from OCA.
Reference
A monotopic membrane protein goes solo., Mattevi A, Structure. 2006 Apr;14(4):628-9. PMID:16615901
Page seeded by OCA on Thu Feb 21 16:57:58 2008
