4h6o

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'''Unreleased structure'''
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{{STRUCTURE_4h6o| PDB=4h6o | SCENE= }}
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===Sterol 14-alpha demethylase (CYP51)from Trypanosoma cruzi in complex with the inhibitor NEU321 (1-(3-(4-chloro-3,5-dimethylphenoxy)benzyl)-1H-imidazole===
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{{ABSTRACT_PUBMED_23448316}}
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The entry 4h6o is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/CP51_TRYCC CP51_TRYCC]] Catalyzes C14-demethylation of lanosterol which is critical for ergosterol biosynthesis. It transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol (By similarity). Favors C4 dimethylated substrates, the substrate preference order is 24-methylenedihydrolanosterol > 24,25-dihydrolanosterol > lanosterol > obtusifoliol > norlanosterol.<ref>PMID:16321980</ref>[UniProtKB:P0A512]
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Authors: Wawrzak, Z., Hargrove, T.Y., Pollastri, M.P., Lepesheva, G.I.
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==About this Structure==
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[[4h6o]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_cruzi Trypanosoma cruzi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H6O OCA].
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Description: Sterol 14-alpha demethylase (CYP51)from Trypanosoma cruzi in complex with the inhibitor NEU321 (1-(3-(4-chloro-3,5-dimethylphenoxy)benzyl)-1H-imidazole
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Sterol 14-demethylase]]
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[[Category: Trypanosoma cruzi]]
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[[Category: Hargrove, T Y.]]
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[[Category: Lepesheva, G I.]]
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[[Category: Pollastri, M P.]]
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[[Category: Wawrzak, Z.]]
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[[Category: Cytochrome p450]]
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[[Category: Cytochrome p450 fold]]
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[[Category: Endoplasmic reticulum membrane]]
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[[Category: Eukaryotic membrane]]
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[[Category: Heme]]
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[[Category: Monooxygenase]]
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[[Category: Oxidoreductase]]
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[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]
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[[Category: Sterol biosynthesis]]

Revision as of 07:42, 27 March 2013

Template:STRUCTURE 4h6o

Contents

Sterol 14-alpha demethylase (CYP51)from Trypanosoma cruzi in complex with the inhibitor NEU321 (1-(3-(4-chloro-3,5-dimethylphenoxy)benzyl)-1H-imidazole

Template:ABSTRACT PUBMED 23448316

Function

[CP51_TRYCC] Catalyzes C14-demethylation of lanosterol which is critical for ergosterol biosynthesis. It transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol (By similarity). Favors C4 dimethylated substrates, the substrate preference order is 24-methylenedihydrolanosterol > 24,25-dihydrolanosterol > lanosterol > obtusifoliol > norlanosterol.[1][UniProtKB:P0A512]

About this Structure

4h6o is a 1 chain structure with sequence from Trypanosoma cruzi. Full crystallographic information is available from OCA.

Reference

  1. ↑ Lepesheva GI, Zaitseva NG, Nes WD, Zhou W, Arase M, Liu J, Hill GC, Waterman MR. CYP51 from Trypanosoma cruzi: a phyla-specific residue in the B' helix defines substrate preferences of sterol 14alpha-demethylase. J Biol Chem. 2006 Feb 10;281(6):3577-85. Epub 2005 Nov 30. PMID:16321980 doi:M510317200

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