2df0

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(New page: 200px<br /> <applet load="2df0" size="450" color="white" frame="true" align="right" spinBox="true" caption="2df0" /> '''Solution structure of human PYY3-36'''<br /...)
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<applet load="2df0" size="450" color="white" frame="true" align="right" spinBox="true"
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'''Solution structure of human PYY3-36'''<br />
'''Solution structure of human PYY3-36'''<br />
==Overview==
==Overview==
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PYY3-36 is a biopharmaceutical antiobesity agent under development as well, as an endogenous satiety hormone, which is generated by dipeptidyl, peptidase-IV digestion of polypetide YY (PYY), and in contrast to the, parent hormone, PYY is highly selective for the Y2 versus the Y1 receptor., NMR analysis revealed a highly ordered, back-folded structure for human, PYY in aqueous solution similar to the classical PP-fold structure of, pancreatic polypeptide. The NMR analysis of PYY3-36 also showed a folded, structure resembling a PP-fold, which however was characterized by far, fewer long distance NOEs than the PP-fold observed in the full-length, peptide. This suggests that either a conformational change has occurred in, the N-terminal segment of PYY3-36 or that this segments is characterized, by larger dynamics. The study supports the notion that the PP-fold is, crucial for establishing simultaneous interactions with two subsites in, the receptor for binding of, respectively, the N- and C-terminal ends of, PYY. The Y2 receptor only requires recognition of the C-terminal segment, of the molecule as displayed by the Y2 selective PYY3-36.
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PYY3-36 is a biopharmaceutical antiobesity agent under development as well as an endogenous satiety hormone, which is generated by dipeptidyl peptidase-IV digestion of polypetide YY (PYY), and in contrast to the parent hormone, PYY is highly selective for the Y2 versus the Y1 receptor. NMR analysis revealed a highly ordered, back-folded structure for human PYY in aqueous solution similar to the classical PP-fold structure of pancreatic polypeptide. The NMR analysis of PYY3-36 also showed a folded structure resembling a PP-fold, which however was characterized by far fewer long distance NOEs than the PP-fold observed in the full-length peptide. This suggests that either a conformational change has occurred in the N-terminal segment of PYY3-36 or that this segments is characterized by larger dynamics. The study supports the notion that the PP-fold is crucial for establishing simultaneous interactions with two subsites in the receptor for binding of, respectively, the N- and C-terminal ends of PYY. The Y2 receptor only requires recognition of the C-terminal segment of the molecule as displayed by the Y2 selective PYY3-36.
==About this Structure==
==About this Structure==
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2DF0 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/ ] with NH2 as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2DF0 OCA].
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2DF0 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/ ] with <scene name='pdbligand=NH2:'>NH2</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DF0 OCA].
==Reference==
==Reference==
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[[Category: pyy]]
[[Category: pyy]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 21:31:40 2007''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:58:09 2008''

Revision as of 14:58, 21 February 2008

Image:2df0.gif

2df0

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Solution structure of human PYY3-36

Overview

PYY3-36 is a biopharmaceutical antiobesity agent under development as well as an endogenous satiety hormone, which is generated by dipeptidyl peptidase-IV digestion of polypetide YY (PYY), and in contrast to the parent hormone, PYY is highly selective for the Y2 versus the Y1 receptor. NMR analysis revealed a highly ordered, back-folded structure for human PYY in aqueous solution similar to the classical PP-fold structure of pancreatic polypeptide. The NMR analysis of PYY3-36 also showed a folded structure resembling a PP-fold, which however was characterized by far fewer long distance NOEs than the PP-fold observed in the full-length peptide. This suggests that either a conformational change has occurred in the N-terminal segment of PYY3-36 or that this segments is characterized by larger dynamics. The study supports the notion that the PP-fold is crucial for establishing simultaneous interactions with two subsites in the receptor for binding of, respectively, the N- and C-terminal ends of PYY. The Y2 receptor only requires recognition of the C-terminal segment of the molecule as displayed by the Y2 selective PYY3-36.

About this Structure

2DF0 is a Single protein structure of sequence from [1] with as ligand. Full crystallographic information is available from OCA.

Reference

The PP-fold solution structure of human polypeptide YY and human PYY3-36 as determined by NMR., Nygaard R, Nielbo S, Schwartz TW, Poulsen FM, Biochemistry. 2006 Jul 11;45(27):8350-7. PMID:16819834

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