4f0x

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
'''Unreleased structure'''
+
{{STRUCTURE_4f0x| PDB=4f0x | SCENE= }}
 +
===Crystal structure of human Malonyl-CoA Decarboxylase (Peroxisomal Isoform)===
 +
{{ABSTRACT_PUBMED_23482565}}
-
The entry 4f0x is ON HOLD until Paper Publication
+
==Disease==
 +
[[http://www.uniprot.org/uniprot/DCMC_HUMAN DCMC_HUMAN]] Malonic aciduria. Defects in MLYCD are the cause of malonyl-CoA decarboxylase deficiency (MLYCD deficiency) [MIM:[http://omim.org/entry/248360 248360]]. MLYCD deficiency is an autosomal recessive disease characterized by abdominal pain, chronic constipation, episodic vomiting, metabolic acidosis and malonic aciduria.
-
Authors: Aparicio, D., Perez, R., Fita, I.
+
==Function==
 +
[[http://www.uniprot.org/uniprot/DCMC_HUMAN DCMC_HUMAN]] Catalyzes the conversion of malonyl-CoA to acetyl-CoA. In the fatty acid biosynthesis MCD selectively removes malonyl-CoA and thus assures that methyl-malonyl-CoA is the only chain elongating substrate for fatty acid synthase and that fatty acids with multiple methyl side chains are produced. In peroxisomes it may be involved in degrading intraperoxisomal malonyl-CoA, which is generated by the peroxisomal beta-oxidation of odd chain-length dicarboxylic fatty acids.
-
Description: Crystal Structure of a Peroxisomal Enzyme
+
==About this Structure==
 +
[[4f0x]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F0X OCA].
 +
[[Category: Homo sapiens]]
 +
[[Category: Malonyl-CoA decarboxylase]]
 +
[[Category: Aparicio, D.]]
 +
[[Category: Fita, I.]]
 +
[[Category: Perez, R.]]
 +
[[Category: Enzyme]]
 +
[[Category: Lyase]]
 +
[[Category: Peroxisome]]

Revision as of 07:45, 27 March 2013

Template:STRUCTURE 4f0x

Contents

Crystal structure of human Malonyl-CoA Decarboxylase (Peroxisomal Isoform)

Template:ABSTRACT PUBMED 23482565

Disease

[DCMC_HUMAN] Malonic aciduria. Defects in MLYCD are the cause of malonyl-CoA decarboxylase deficiency (MLYCD deficiency) [MIM:248360]. MLYCD deficiency is an autosomal recessive disease characterized by abdominal pain, chronic constipation, episodic vomiting, metabolic acidosis and malonic aciduria.

Function

[DCMC_HUMAN] Catalyzes the conversion of malonyl-CoA to acetyl-CoA. In the fatty acid biosynthesis MCD selectively removes malonyl-CoA and thus assures that methyl-malonyl-CoA is the only chain elongating substrate for fatty acid synthase and that fatty acids with multiple methyl side chains are produced. In peroxisomes it may be involved in degrading intraperoxisomal malonyl-CoA, which is generated by the peroxisomal beta-oxidation of odd chain-length dicarboxylic fatty acids.

About this Structure

4f0x is a 8 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4f0x"
Personal tools