1mnn

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[[Image:1mnn.png|left|200px]]
 
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{{STRUCTURE_1mnn| PDB=1mnn | SCENE= }}
{{STRUCTURE_1mnn| PDB=1mnn | SCENE= }}
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===Structure of the sporulation specific transcription factor Ndt80 bound to DNA===
===Structure of the sporulation specific transcription factor Ndt80 bound to DNA===
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{{ABSTRACT_PUBMED_12411490}}
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{{ABSTRACT_PUBMED_12411490}}
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==Function==
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[[http://www.uniprot.org/uniprot/NDT80_YEAST NDT80_YEAST]] Transcription factor required for successful completion of meiosis and spore formation. Gets activated after completion of meiotic recombination at the end of prophase I. Recognizes and binds to the middle sporulation element (MSE) 5'-C[AG]CAAA[AT]-3' in the promoter region of stage-specific genes that are required for progression through meiosis and sporulation. Competes for binding to MSE with the transcriptional repressor SUM1, which represses middle sporulation-specific genes during mitosis and early sporulation.<ref>PMID:8524222</ref><ref>PMID:9660952</ref><ref>PMID:9742092</ref><ref>PMID:12832469</ref>
==About this Structure==
==About this Structure==
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==Reference==
==Reference==
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<ref group="xtra">PMID:012411490</ref><references group="xtra"/>
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<ref group="xtra">PMID:012411490</ref><references group="xtra"/><references/>
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Glover, J N.]]
[[Category: Glover, J N.]]

Revision as of 07:46, 27 March 2013

Template:STRUCTURE 1mnn

Contents

Structure of the sporulation specific transcription factor Ndt80 bound to DNA

Template:ABSTRACT PUBMED 12411490

Function

[NDT80_YEAST] Transcription factor required for successful completion of meiosis and spore formation. Gets activated after completion of meiotic recombination at the end of prophase I. Recognizes and binds to the middle sporulation element (MSE) 5'-C[AG]CAAA[AT]-3' in the promoter region of stage-specific genes that are required for progression through meiosis and sporulation. Competes for binding to MSE with the transcriptional repressor SUM1, which represses middle sporulation-specific genes during mitosis and early sporulation.[1][2][3][4]

About this Structure

1mnn is a 3 chain structure with sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

  • Lamoureux JS, Stuart D, Tsang R, Wu C, Glover JN. Structure of the sporulation-specific transcription factor Ndt80 bound to DNA. EMBO J. 2002 Nov 1;21(21):5721-32. PMID:12411490
  1. ↑ Xu L, Ajimura M, Padmore R, Klein C, Kleckner N. NDT80, a meiosis-specific gene required for exit from pachytene in Saccharomyces cerevisiae. Mol Cell Biol. 1995 Dec;15(12):6572-81. PMID:8524222
  2. ↑ Chu S, Herskowitz I. Gametogenesis in yeast is regulated by a transcriptional cascade dependent on Ndt80. Mol Cell. 1998 Apr;1(5):685-96. PMID:9660952
  3. ↑ Hepworth SR, Friesen H, Segall J. NDT80 and the meiotic recombination checkpoint regulate expression of middle sporulation-specific genes in Saccharomyces cerevisiae. Mol Cell Biol. 1998 Oct;18(10):5750-61. PMID:9742092
  4. ↑ Pierce M, Benjamin KR, Montano SP, Georgiadis MM, Winter E, Vershon AK. Sum1 and Ndt80 proteins compete for binding to middle sporulation element sequences that control meiotic gene expression. Mol Cell Biol. 2003 Jul;23(14):4814-25. PMID:12832469

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