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4hka

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'''Unreleased structure'''
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{{STRUCTURE_4hka| PDB=4hka | SCENE= }}
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===Crystal structure of Drosophila melanogaster tryptophan 2,3-dioxygenase in complex with HEME===
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{{ABSTRACT_PUBMED_23333332}}
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The entry 4hka is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/T23O_DROME T23O_DROME]] Catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring (By similarity). Required during larval growth to control the level of potentially harmful free tryptophan in the hemolymph. In the adult the same reaction is the first step in the ommochrome biosynthetic pathway.<ref>PMID:2108317</ref>
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Authors: Huang, W., Ding, J.
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==About this Structure==
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[[4hka]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HKA OCA].
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Description: Crystal structure of Drosophila melanogaster tryptophan 2,3-dioxygenase in complex with HEME
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Drosophila melanogaster]]
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[[Category: Tryptophan 2,3-dioxygenase]]
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[[Category: Ding, J.]]
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[[Category: Huang, W.]]
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[[Category: Catalytic mechanism]]
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[[Category: Kynurenine pathway]]
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[[Category: Oxidoreductase]]
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[[Category: Regulatory mechanism]]

Revision as of 08:45, 27 March 2013

Template:STRUCTURE 4hka

Contents

Crystal structure of Drosophila melanogaster tryptophan 2,3-dioxygenase in complex with HEME

Template:ABSTRACT PUBMED 23333332

Function

[T23O_DROME] Catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring (By similarity). Required during larval growth to control the level of potentially harmful free tryptophan in the hemolymph. In the adult the same reaction is the first step in the ommochrome biosynthetic pathway.[1]

About this Structure

4hka is a 1 chain structure with sequence from Drosophila melanogaster. Full crystallographic information is available from OCA.

Reference

  1. ↑ Searles LL, Ruth RS, Pret AM, Fridell RA, Ali AJ. Structure and transcription of the Drosophila melanogaster vermilion gene and several mutant alleles. Mol Cell Biol. 1990 Apr;10(4):1423-31. PMID:2108317

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