1l3x

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===Solution Structure of Novel Disintegrin Salmosin===
===Solution Structure of Novel Disintegrin Salmosin===
{{ABSTRACT_PUBMED_14661951}}
{{ABSTRACT_PUBMED_14661951}}
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==Function==
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[[http://www.uniprot.org/uniprot/VM2HS_GLOBR VM2HS_GLOBR]] Metalloproteinase hxl-1: snake venom metalloproteinase that impairs hemostasis in the envenomed animal (By similarity).<ref>PMID:9722022</ref><ref>PMID:9856345</ref><ref>PMID:10446992</ref><ref>PMID:10944460</ref><ref>PMID:14977354</ref> Disintegrin salmosin-1: inhibits GPIIb/GPIIIa (ITGA2B/ITGB3) binding to immobilized fibrinogen with an IC(50) of 2.2 nM and ADP-induced platelet aggregation with an IC(50) of 131 nM, respectively. Inhibits angiogenesis.<ref>PMID:9722022</ref><ref>PMID:9856345</ref><ref>PMID:10446992</ref><ref>PMID:10944460</ref><ref>PMID:14977354</ref>
==About this Structure==
==About this Structure==
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==Reference==
==Reference==
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<ref group="xtra">PMID:014661951</ref><references group="xtra"/>
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<ref group="xtra">PMID:014661951</ref><references group="xtra"/><references/>
[[Category: Gloydius brevicaudus]]
[[Category: Gloydius brevicaudus]]
[[Category: Lee, W.]]
[[Category: Lee, W.]]

Revision as of 08:49, 27 March 2013

Template:STRUCTURE 1l3x

Contents

Solution Structure of Novel Disintegrin Salmosin

Template:ABSTRACT PUBMED 14661951

Function

[VM2HS_GLOBR] Metalloproteinase hxl-1: snake venom metalloproteinase that impairs hemostasis in the envenomed animal (By similarity).[1][2][3][4][5] Disintegrin salmosin-1: inhibits GPIIb/GPIIIa (ITGA2B/ITGB3) binding to immobilized fibrinogen with an IC(50) of 2.2 nM and ADP-induced platelet aggregation with an IC(50) of 131 nM, respectively. Inhibits angiogenesis.[6][7][8][9][10]

About this Structure

1l3x is a 1 chain structure with sequence from Gloydius brevicaudus. This structure supersedes the now removed PDB entry 1iq2. Full experimental information is available from OCA.

See Also

Reference

  • Shin J, Hong SY, Chung K, Kang I, Jang Y, Kim DS, Lee W. Solution structure of a novel disintegrin, salmosin, from Agkistrondon halys venom. Biochemistry. 2003 Dec 16;42(49):14408-15. PMID:14661951 doi:10.1021/bi0300276
  1. ↑ Kang IC, Chung KH, Lee SJ, Yun Y, Moon HM, Kim DS. Purification and molecular cloning of a platelet aggregation inhibitor from the snake (Agkistrodon halys brevicaudus) venom. Thromb Res. 1998 Jul 15;91(2):65-73. PMID:9722022
  2. ↑ Park D, Kang I, Kim H, Chung K, Kim DS, Yun Y. Cloning and characterization of novel disintegrins from Agkistrodon halys venom. Mol Cells. 1998 Oct 31;8(5):578-84. PMID:9856345
  3. ↑ Kang IC, Lee YD, Kim DS. A novel disintegrin salmosin inhibits tumor angiogenesis. Cancer Res. 1999 Aug 1;59(15):3754-60. PMID:10446992
  4. ↑ Kang IC, Kim DS, Jang Y, Chung KH. Suppressive mechanism of salmosin, a novel disintegrin in B16 melanoma cell metastasis. Biochem Biophys Res Commun. 2000 Aug 18;275(1):169-73. PMID:10944460 doi:10.1006/bbrc.2000.3130
  5. ↑ Kim SI, Kim KS, Kim HS, Choi MM, Kim DS, Chung KH, Park YS. Inhibition of angiogenesis by salmosin expressed in vitro. Oncol Res. 2004;14(4-5):227-33. PMID:14977354
  6. ↑ Kang IC, Chung KH, Lee SJ, Yun Y, Moon HM, Kim DS. Purification and molecular cloning of a platelet aggregation inhibitor from the snake (Agkistrodon halys brevicaudus) venom. Thromb Res. 1998 Jul 15;91(2):65-73. PMID:9722022
  7. ↑ Park D, Kang I, Kim H, Chung K, Kim DS, Yun Y. Cloning and characterization of novel disintegrins from Agkistrodon halys venom. Mol Cells. 1998 Oct 31;8(5):578-84. PMID:9856345
  8. ↑ Kang IC, Lee YD, Kim DS. A novel disintegrin salmosin inhibits tumor angiogenesis. Cancer Res. 1999 Aug 1;59(15):3754-60. PMID:10446992
  9. ↑ Kang IC, Kim DS, Jang Y, Chung KH. Suppressive mechanism of salmosin, a novel disintegrin in B16 melanoma cell metastasis. Biochem Biophys Res Commun. 2000 Aug 18;275(1):169-73. PMID:10944460 doi:10.1006/bbrc.2000.3130
  10. ↑ Kim SI, Kim KS, Kim HS, Choi MM, Kim DS, Chung KH, Park YS. Inhibition of angiogenesis by salmosin expressed in vitro. Oncol Res. 2004;14(4-5):227-33. PMID:14977354

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