3znr

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "3znr" [edit=sysop:move=sysop])
Line 1: Line 1:
-
'''Unreleased structure'''
+
{{STRUCTURE_3znr| PDB=3znr | SCENE= }}
 +
===HDAC7 bound with inhibitor TMP269===
-
The entry 3znr is ON HOLD
+
==Function==
 +
[[http://www.uniprot.org/uniprot/HDAC7_HUMAN HDAC7_HUMAN]] Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer factors such as MEF2A, MEF2B and MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors (By similarity). May be involved in Epstein-Barr virus (EBV) latency, possibly by repressing the viral BZLF1 gene.<ref>PMID:12239305</ref>
-
Authors: Lobera, m., madauss, k., pohlhaus, d., trump, r., nolan, m.
+
==About this Structure==
 +
[[3znr]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZNR OCA].
-
Description: HDAC7 bound with inhibitor TMP269
+
==Reference==
 +
<references group="xtra"/><references/>
 +
[[Category: Histone deacetylase]]
 +
[[Category: Homo sapiens]]
 +
[[Category: Lobera, m.]]
 +
[[Category: Madauss, k.]]
 +
[[Category: Nolan, m.]]
 +
[[Category: Pohlhaus, d.]]
 +
[[Category: Trump, r.]]
 +
[[Category: Class iia hdac]]
 +
[[Category: Hydrolase]]
 +
[[Category: Tfmo]]

Revision as of 08:54, 27 March 2013

Template:STRUCTURE 3znr

Contents

HDAC7 bound with inhibitor TMP269

Function

[HDAC7_HUMAN] Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer factors such as MEF2A, MEF2B and MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors (By similarity). May be involved in Epstein-Barr virus (EBV) latency, possibly by repressing the viral BZLF1 gene.[1]

About this Structure

3znr is a 3 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  1. ↑ Bryant H, Farrell PJ. Signal Transduction and Transcription Factor Modification during Reactivation of Epstein-Barr Virus from Latency. J Virol. 2002 Oct;76(20):10290-8. PMID:12239305

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3znr"
Personal tools