4e01
From Proteopedia
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- | + | {{STRUCTURE_4e01| PDB=4e01 | SCENE= }} | |
+ | ===Crystal structure of branched-chain alpha-ketoacid dehydrogenase kinase/3,6-dichlorobenzo[b]thiophene-2-carboxylic acid complex with AMPPNP=== | ||
- | + | ==Function== | |
+ | [[http://www.uniprot.org/uniprot/BCKD_RAT BCKD_RAT]] Catalyzes the phosphorylation and inactivation of the branched-chain alpha-ketoacid dehydrogenase complex, the key regulatory enzyme of the valine, leucine and isoleucine catabolic pathways. Key enzyme that regulate the activity state of the BCKD complex. | ||
- | + | ==About this Structure== | |
- | + | [[4e01]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4E01 OCA]. | |
- | + | [[Category: Rattus norvegicus]] | |
+ | [[Category: Chuang, D T.]] | ||
+ | [[Category: Chuang, J L.]] | ||
+ | [[Category: Gui, W J.]] | ||
+ | [[Category: Li, J.]] | ||
+ | [[Category: Tso, S C.]] | ||
+ | [[Category: Wynn, R M.]] | ||
+ | [[Category: Allosteric kinase inhibitor]] | ||
+ | [[Category: Bergerat nucleotide-binding fold]] | ||
+ | [[Category: Branched-chain alpha-ketoacid]] | ||
+ | [[Category: Branched-chain amino acid]] | ||
+ | [[Category: Diabetes and obesity]] | ||
+ | [[Category: Ghkl protein kinase]] | ||
+ | [[Category: Maple syrup urine disease]] | ||
+ | [[Category: Protein kinase]] | ||
+ | [[Category: Transferase-transferase inhibitor complex]] |
Revision as of 08:57, 27 March 2013
Crystal structure of branched-chain alpha-ketoacid dehydrogenase kinase/3,6-dichlorobenzo[b]thiophene-2-carboxylic acid complex with AMPPNP
Function
[BCKD_RAT] Catalyzes the phosphorylation and inactivation of the branched-chain alpha-ketoacid dehydrogenase complex, the key regulatory enzyme of the valine, leucine and isoleucine catabolic pathways. Key enzyme that regulate the activity state of the BCKD complex.
About this Structure
4e01 is a 1 chain structure with sequence from Rattus norvegicus. Full crystallographic information is available from OCA.
Categories: Rattus norvegicus | Chuang, D T. | Chuang, J L. | Gui, W J. | Li, J. | Tso, S C. | Wynn, R M. | Allosteric kinase inhibitor | Bergerat nucleotide-binding fold | Branched-chain alpha-ketoacid | Branched-chain amino acid | Diabetes and obesity | Ghkl protein kinase | Maple syrup urine disease | Protein kinase | Transferase-transferase inhibitor complex