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4igz

From Proteopedia

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'''Unreleased structure'''
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{{STRUCTURE_4igz| PDB=4igz | SCENE= }}
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===Crystal structure of the SH3 domain of human sorbin and SH3 domain-containing protein 2===
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The entry 4igz is ON HOLD until sometime in the future
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==Function==
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[[http://www.uniprot.org/uniprot/SRBS2_HUMAN SRBS2_HUMAN]] Adapter protein that plays a role in the assembling of signaling complexes, being a link between ABL kinases and actin cytoskeleton. Can form complex with ABL1 and CBL, thus promoting ubiquitination and degradation of ABL1 or with AKT1 and PAK1, thus mediating AKT1-mediated activation of PAK1. Isoform 6 increases water and sodium absorption in the intestine and gall-bladder.<ref>PMID:9211900</ref><ref>PMID:12475393</ref>
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Authors: Liu, Y., Tempel, W., Huang, H., Gu, J., Liu, K., El Bakkouri, M., Sidhu, S.S., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
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==About this Structure==
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[[4igz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IGZ OCA].
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Description: Crystal structure of the SH3 domain of human sorbin and SH3 domain-containing protein 2
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Homo sapiens]]
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[[Category: Arrowsmith, C H.]]
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[[Category: Bakkouri, M El.]]
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[[Category: Bountra, C.]]
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[[Category: Edwards, A M.]]
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[[Category: Gu, J.]]
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[[Category: Huang, H.]]
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[[Category: Liu, K.]]
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[[Category: Liu, Y.]]
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[[Category: Min, J.]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Sidhu, S S.]]
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[[Category: Tempel, W.]]
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[[Category: Protein binding]]
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[[Category: Sgc]]
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[[Category: Sh3]]
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[[Category: Src homology 3 domain]]
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[[Category: Structural genomics consortium]]

Revision as of 09:01, 27 March 2013

Template:STRUCTURE 4igz

Contents

Crystal structure of the SH3 domain of human sorbin and SH3 domain-containing protein 2

Function

[SRBS2_HUMAN] Adapter protein that plays a role in the assembling of signaling complexes, being a link between ABL kinases and actin cytoskeleton. Can form complex with ABL1 and CBL, thus promoting ubiquitination and degradation of ABL1 or with AKT1 and PAK1, thus mediating AKT1-mediated activation of PAK1. Isoform 6 increases water and sodium absorption in the intestine and gall-bladder.[1][2]

About this Structure

4igz is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  1. ↑ Wang B, Golemis EA, Kruh GD. ArgBP2, a multiple Src homology 3 domain-containing, Arg/Abl-interacting protein, is phosphorylated in v-Abl-transformed cells and localized in stress fibers and cardiocyte Z-disks. J Biol Chem. 1997 Jul 11;272(28):17542-50. PMID:9211900
  2. ↑ Soubeyran P, Barac A, Szymkiewicz I, Dikic I. Cbl-ArgBP2 complex mediates ubiquitination and degradation of c-Abl. Biochem J. 2003 Feb 15;370(Pt 1):29-34. PMID:12475393 doi:10.1042/BJ20021539

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OCA

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