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3ff9

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[[Image:3ff9.png|left|200px]]
 
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{{STRUCTURE_3ff9| PDB=3ff9 | SCENE= }}
{{STRUCTURE_3ff9| PDB=3ff9 | SCENE= }}
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===Structure of NK cell receptor KLRG1===
===Structure of NK cell receptor KLRG1===
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{{ABSTRACT_PUBMED_19604491}}
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==Function==
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[[http://www.uniprot.org/uniprot/KLRG1_MOUSE KLRG1_MOUSE]] Plays an inhibitory role on natural killer (NK) cells and T-cell functions upon binding to their non-MHC ligands. May mediate missing self recognition by binding to a highly conserved site on classical cadherins, enabling it to monitor expression of E-cadherin/CDH1, N-cadherin/CDH2 and R-cadherin/CDH4 on target cells.<ref>PMID:19604491</ref>
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{{ABSTRACT_PUBMED_19604491}}
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==About this Structure==
==About this Structure==
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==Reference==
==Reference==
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<ref group="xtra">PMID:019604491</ref><references group="xtra"/>
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<ref group="xtra">PMID:019604491</ref><references group="xtra"/><references/>
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Li, Y.]]
[[Category: Li, Y.]]

Revision as of 09:11, 27 March 2013

Template:STRUCTURE 3ff9

Contents

Structure of NK cell receptor KLRG1

Template:ABSTRACT PUBMED 19604491

Function

[KLRG1_MOUSE] Plays an inhibitory role on natural killer (NK) cells and T-cell functions upon binding to their non-MHC ligands. May mediate missing self recognition by binding to a highly conserved site on classical cadherins, enabling it to monitor expression of E-cadherin/CDH1, N-cadherin/CDH2 and R-cadherin/CDH4 on target cells.[1]

About this Structure

3ff9 is a 2 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

  • Li Y, Hofmann M, Wang Q, Teng L, Chlewicki LK, Pircher H, Mariuzza RA. Structure of natural killer cell receptor KLRG1 bound to E-cadherin reveals basis for MHC-independent missing self recognition. Immunity. 2009 Jul 17;31(1):35-46. PMID:19604491 doi:S1074-7613(09)00276-3
  1. ↑ Li Y, Hofmann M, Wang Q, Teng L, Chlewicki LK, Pircher H, Mariuzza RA. Structure of natural killer cell receptor KLRG1 bound to E-cadherin reveals basis for MHC-independent missing self recognition. Immunity. 2009 Jul 17;31(1):35-46. PMID:19604491 doi:S1074-7613(09)00276-3

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