3iwz

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Template:STRUCTURE 3iwz

Contents

The c-di-GMP Responsive Global Regulator CLP Links Cell-Cell Signaling to Virulence Gene Expression in Xanthomonas campestris

Template:ABSTRACT PUBMED 020004667

Function

[CLP_XANCP] Global transcriptional regulator that regulates virulence factors production by activating or repressing the expression of a large set of genes in diffusible signal factor (DSF) pathway. It includes, among others, genes involved in extracellular polysaccharide (EPS) synthesis, flagellum synthesis, protein and fatty acid metabolism, multidrug resistance, iron uptake or genes encoding extracellular enzymes, membrane components and a few transcription factors. Regulation can be direct or indirect, via regulation of other transcriptional regulators. Not involved in DSF-mediated biofilm dispersal.[1]

About this Structure

3iwz is a 4 chain structure with sequence from Xanthomonas campestris pv. campestris. Full crystallographic information is available from OCA.

Reference

  1. ↑ He YW, Ng AY, Xu M, Lin K, Wang LH, Dong YH, Zhang LH. Xanthomonas campestris cell-cell communication involves a putative nucleotide receptor protein Clp and a hierarchical signalling network. Mol Microbiol. 2007 Apr;64(2):281-92. Epub 2007 Mar 23. PMID:17378922 doi:10.1111/j.1365-2958.2007.05670.x

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OCA

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