3jtp

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{{STRUCTURE_3jtp| PDB=3jtp | SCENE= }}
{{STRUCTURE_3jtp| PDB=3jtp | SCENE= }}
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===crystal structure of the C-terminal domain of MecA===
===crystal structure of the C-terminal domain of MecA===
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{{ABSTRACT_PUBMED_019801546}}
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==Function==
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[[http://www.uniprot.org/uniprot/MECA1_BACSU MECA1_BACSU]] Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis. Acts negatively in the development of competence by binding ComK and recruiting it to the ClpCP protease. When overexpressed, inhibits sporulation. Also involved in Spx degradation by ClpC.<ref>PMID:12598648</ref>
==About this Structure==
==About this Structure==
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3JTP is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JTP OCA].
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[[3jtp]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JTP OCA].
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==Reference==
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<references group="xtra"/><references/>
[[Category: Bacillus subtilis]]
[[Category: Bacillus subtilis]]
[[Category: Mei, Z.]]
[[Category: Mei, Z.]]
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[[Category: Protein binding]]
[[Category: Protein binding]]
[[Category: Sporulation]]
[[Category: Sporulation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 30 09:32:42 2009''
 

Revision as of 09:15, 27 March 2013

Template:STRUCTURE 3jtp

Contents

crystal structure of the C-terminal domain of MecA

Template:ABSTRACT PUBMED 019801546

Function

[MECA1_BACSU] Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis. Acts negatively in the development of competence by binding ComK and recruiting it to the ClpCP protease. When overexpressed, inhibits sporulation. Also involved in Spx degradation by ClpC.[1]

About this Structure

3jtp is a 4 chain structure with sequence from Bacillus subtilis. Full crystallographic information is available from OCA.

Reference

  1. ↑ Schlothauer T, Mogk A, Dougan DA, Bukau B, Turgay K. MecA, an adaptor protein necessary for ClpC chaperone activity. Proc Natl Acad Sci U S A. 2003 Mar 4;100(5):2306-11. Epub 2003 Feb 21. PMID:12598648 doi:10.1073/pnas.0535717100

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