3izo
From Proteopedia
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{{STRUCTURE_3izo| PDB=3izo | SCENE= }} | {{STRUCTURE_3izo| PDB=3izo | SCENE= }} | ||
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===Model of the fiber tail and its interactions with the penton base of human adenovirus by cryo-electron microscopy=== | ===Model of the fiber tail and its interactions with the penton base of human adenovirus by cryo-electron microscopy=== | ||
| + | {{ABSTRACT_PUBMED_21146538}} | ||
| - | + | ==Function== | |
| - | + | [[http://www.uniprot.org/uniprot/PEN3_ADE05 PEN3_ADE05]] Major capsid protein that self-associates to form penton base pentamers, each in the shape of a pentagon, situated at the 12 verteces of the pseudo T=25 capsid. Involved in virus secondary attachment to host cell after initial attachment by the fiber protein. Binds host integrin heterodimer ITGAV-ITGB5 (alphaV-beta5) thereby triggering clathrin-mediated endocytosis of virions. Mediates initial virus attachment to CXADR-negative cells. Binding to integrins ITGAV-ITGB5 also seems to induce macropinocytosis uptake of the virus. As the virus enters the host cell, penton proteins are shedded concomitant with virion acidification in the endosome.<ref>PMID:20615244</ref><ref>PMID:20798312</ref> | |
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==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID: | + | <ref group="xtra">PMID:021146538</ref><references group="xtra"/><references/> |
[[Category: Human adenovirus 5]] | [[Category: Human adenovirus 5]] | ||
[[Category: Liu, H.]] | [[Category: Liu, H.]] | ||
| + | [[Category: Human adenovirus fiber tail]] | ||
| + | [[Category: Pentameric penton base]] | ||
| + | [[Category: Trimeric fiber]] | ||
| + | [[Category: Viral protein]] | ||
Revision as of 09:19, 27 March 2013
Contents |
Model of the fiber tail and its interactions with the penton base of human adenovirus by cryo-electron microscopy
Template:ABSTRACT PUBMED 21146538
Function
[PEN3_ADE05] Major capsid protein that self-associates to form penton base pentamers, each in the shape of a pentagon, situated at the 12 verteces of the pseudo T=25 capsid. Involved in virus secondary attachment to host cell after initial attachment by the fiber protein. Binds host integrin heterodimer ITGAV-ITGB5 (alphaV-beta5) thereby triggering clathrin-mediated endocytosis of virions. Mediates initial virus attachment to CXADR-negative cells. Binding to integrins ITGAV-ITGB5 also seems to induce macropinocytosis uptake of the virus. As the virus enters the host cell, penton proteins are shedded concomitant with virion acidification in the endosome.[1][2]
About this Structure
3izo is a 8 chain structure with sequence from Human adenovirus 5. Full crystallographic information is available from OCA.
Reference
- Liu H, Wu L, Zhou ZH. Model of the Trimeric Fiber and Its Interactions with the Pentameric Penton Base of Human Adenovirus by Cryo-electron Microscopy. J Mol Biol. 2010 Dec 10. PMID:21146538 doi:10.1016/j.jmb.2010.11.043
- ↑ Lyle C, McCormick F. Integrin alphavbeta5 is a primary receptor for adenovirus in CAR-negative cells. Virol J. 2010 Jul 8;7:148. doi: 10.1186/1743-422X-7-148. PMID:20615244 doi:10.1186/1743-422X-7-148
- ↑ Liu H, Jin L, Koh SB, Atanasov I, Schein S, Wu L, Zhou ZH. Atomic structure of human adenovirus by cryo-EM reveals interactions among protein networks. Science. 2010 Aug 27;329(5995):1038-43. PMID:20798312 doi:10.1126/science.1187433
