3f53

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[[Image:3f53.png|left|200px]]
 
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{{STRUCTURE_3f53| PDB=3f53 | SCENE= }}
{{STRUCTURE_3f53| PDB=3f53 | SCENE= }}
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===Crystal structure of Toxoplasma gondii micronemal protein 1 bound to 2F-3'SiaLacNAc===
===Crystal structure of Toxoplasma gondii micronemal protein 1 bound to 2F-3'SiaLacNAc===
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{{ABSTRACT_PUBMED_19593815}}
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==Function==
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[[http://www.uniprot.org/uniprot/MIC1_TOXGO MIC1_TOXGO]] Adhesin. Required for attachment of the parasite to the host cell prior to invasion. Ensures correct folding of MIC6 and transport of the MIC6-MIC1-MIC4 complex into the micronemes.<ref>PMID:11447133</ref><ref>PMID:11157983</ref><ref>PMID:16166092</ref><ref>PMID:17491595</ref><ref>PMID:9027753</ref>
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{{ABSTRACT_PUBMED_19593815}}
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==About this Structure==
==About this Structure==
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[[3f53]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Toxoplasma_gondii_rh Toxoplasma gondii rh]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F53 OCA].
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[[3f53]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Toxoplasma_gondii Toxoplasma gondii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F53 OCA].
==Reference==
==Reference==
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<ref group="xtra">PMID:019593815</ref><ref group="xtra">PMID:017491595</ref><references group="xtra"/>
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<ref group="xtra">PMID:019593815</ref><ref group="xtra">PMID:017491595</ref><references group="xtra"/><references/>
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[[Category: Toxoplasma gondii rh]]
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[[Category: Toxoplasma gondii]]
[[Category: Garnett, J A.]]
[[Category: Garnett, J A.]]
[[Category: Carbohydrate]]
[[Category: Carbohydrate]]

Revision as of 09:22, 27 March 2013

Template:STRUCTURE 3f53

Contents

Crystal structure of Toxoplasma gondii micronemal protein 1 bound to 2F-3'SiaLacNAc

Template:ABSTRACT PUBMED 19593815

Function

[MIC1_TOXGO] Adhesin. Required for attachment of the parasite to the host cell prior to invasion. Ensures correct folding of MIC6 and transport of the MIC6-MIC1-MIC4 complex into the micronemes.[1][2][3][4][5]

About this Structure

3f53 is a 1 chain structure with sequence from Toxoplasma gondii. Full crystallographic information is available from OCA.

Reference

  • Garnett JA, Liu Y, Leon E, Allman S, Friedrich N, Saouros S, Curry S, Soldati-Favre D, Davis B, Feizi T, Matthews S. Detailed insights from microarray and crystallographic studies into carbohydrate recognition by microneme protein 1 (MIC1) of Toxoplasma gondii. Protein Sci. 2009 Jul 10. PMID:19593815 doi:10.1002/pro.204
  • Blumenschein TM, Friedrich N, Childs RA, Saouros S, Carpenter EP, Campanero-Rhodes MA, Simpson P, Chai W, Koutroukides T, Blackman MJ, Feizi T, Soldati-Favre D, Matthews S. Atomic resolution insight into host cell recognition by Toxoplasma gondii. EMBO J. 2007 Jun 6;26(11):2808-20. Epub 2007 May 10. PMID:17491595
  1. ↑ Lourenco EV, Pereira SR, Faca VM, Coelho-Castelo AA, Mineo JR, Roque-Barreira MC, Greene LJ, Panunto-Castelo A. Toxoplasma gondii micronemal protein MIC1 is a lactose-binding lectin. Glycobiology. 2001 Jul;11(7):541-7. PMID:11447133
  2. ↑ Reiss M, Viebig N, Brecht S, Fourmaux MN, Soete M, Di Cristina M, Dubremetz JF, Soldati D. Identification and characterization of an escorter for two secretory adhesins in Toxoplasma gondii. J Cell Biol. 2001 Feb 5;152(3):563-78. PMID:11157983
  3. ↑ Saouros S, Edwards-Jones B, Reiss M, Sawmynaden K, Cota E, Simpson P, Dowse TJ, Jakle U, Ramboarina S, Shivarattan T, Matthews S, Soldati-Favre D. A novel galectin-like domain from Toxoplasma gondii micronemal protein 1 assists the folding, assembly, and transport of a cell adhesion complex. J Biol Chem. 2005 Nov 18;280(46):38583-91. Epub 2005 Sep 15. PMID:16166092 doi:C500365200
  4. ↑ Blumenschein TM, Friedrich N, Childs RA, Saouros S, Carpenter EP, Campanero-Rhodes MA, Simpson P, Chai W, Koutroukides T, Blackman MJ, Feizi T, Soldati-Favre D, Matthews S. Atomic resolution insight into host cell recognition by Toxoplasma gondii. EMBO J. 2007 Jun 6;26(11):2808-20. Epub 2007 May 10. PMID:17491595
  5. ↑ Fourmaux MN, Achbarou A, Mercereau-Puijalon O, Biderre C, Briche I, Loyens A, Odberg-Ferragut C, Camus D, Dubremetz JF. The MIC1 microneme protein of Toxoplasma gondii contains a duplicated receptor-like domain and binds to host cell surface. Mol Biochem Parasitol. 1996 Dec 20;83(2):201-10. PMID:9027753

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