3jvk

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Revision as of 09:22, 27 March 2013

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Template:STRUCTURE 3jvk

Contents 1 Crystal structure of bromodomain 1 of mouse Brd4 in complex with histone H3-K(ac)14 2 Function 3 About this Structure 4 Reference

Crystal structure of bromodomain 1 of mouse Brd4 in complex with histone H3-K(ac)14

Template:ABSTRACT PUBMED 19828451

Function

[BRD4_MOUSE] Plays a role in a process governing chromosomal dynamics during mitosis.^[1]

About this Structure

3jvk is a 2 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

• Vollmuth F, Blankenfeldt W, Geyer M. Structures of the dual bromodomains of the P-TEFb-activating protein Brd4 at atomic resolution. J Biol Chem. 2009 Dec 25;284(52):36547-56. Epub 2009 Oct 13. PMID:19828451 doi:10.1074/jbc.M109.033712

1. ↑ Dey A, Ellenberg J, Farina A, Coleman AE, Maruyama T, Sciortino S, Lippincott-Schwartz J, Ozato K. A bromodomain protein, MCAP, associates with mitotic chromosomes and affects G(2)-to-M transition. Mol Cell Biol. 2000 Sep;20(17):6537-49. PMID:10938129