2xga

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m (Protected "2xga" [edit=sysop:move=sysop])
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[[Image:2xga.png|left|200px]]
 
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{{STRUCTURE_2xga| PDB=2xga | SCENE= }}
{{STRUCTURE_2xga| PDB=2xga | SCENE= }}
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===MTSL SPIN-LABELLED SHIGELLA FLEXNERI SPA15===
===MTSL SPIN-LABELLED SHIGELLA FLEXNERI SPA15===
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{{ABSTRACT_PUBMED_21075116}}
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==Function==
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[[http://www.uniprot.org/uniprot/SPAK_SHIFL SPAK_SHIFL]] Required for surface presentation of invasion plasmid antigens. Chaperone specialized in the storage of effectors within the bacterial cytoplasm, maintaining them in a secretion-competent state, and allowing their immediate delivery to target cells upon contact of the bacterium with the host cells. Has been shown to chaperone IpaA, IpgB1, OspC3 and probably also OspB.
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(as it appears on PubMed at http://www.pubmed.gov), where 21075116 is the PubMed ID number.
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{{ABSTRACT_PUBMED_21075116}}
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==About this Structure==
==About this Structure==
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==Reference==
==Reference==
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<ref group="xtra">PMID:021075116</ref><references group="xtra"/>
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<ref group="xtra">PMID:021075116</ref><references group="xtra"/><references/>
[[Category: Shigella flexneri]]
[[Category: Shigella flexneri]]
[[Category: Johnson, S.]]
[[Category: Johnson, S.]]
[[Category: Lea, S M.]]
[[Category: Lea, S M.]]
[[Category: Lillington, J E.D.]]
[[Category: Lillington, J E.D.]]
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[[Category: Chaperone]]
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[[Category: Virulence factor]]

Revision as of 09:22, 27 March 2013

Template:STRUCTURE 2xga

Contents

MTSL SPIN-LABELLED SHIGELLA FLEXNERI SPA15

Template:ABSTRACT PUBMED 21075116

Function

[SPAK_SHIFL] Required for surface presentation of invasion plasmid antigens. Chaperone specialized in the storage of effectors within the bacterial cytoplasm, maintaining them in a secretion-competent state, and allowing their immediate delivery to target cells upon contact of the bacterium with the host cells. Has been shown to chaperone IpaA, IpgB1, OspC3 and probably also OspB.

About this Structure

2xga is a 2 chain structure with sequence from Shigella flexneri. Full crystallographic information is available from OCA.

Reference

  • Lillington JE, Lovett JE, Johnson S, Roversi P, Timmel CR, Lea SM. Shigella flexneri Spa15 Crystal Structure Verified in Solution by Double Electron Electron Resonance. J Mol Biol. 2010 Nov 12. PMID:21075116 doi:10.1016/j.jmb.2010.10.053

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OCA

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