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3isj
From Proteopedia
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===Crystal structure of pantothenate synthetase from Mycobacterium tuberculosis in complex with 5-methoxy-N-(methylsulfonyl)-1H-indole-2-carboxamide=== | ===Crystal structure of pantothenate synthetase from Mycobacterium tuberculosis in complex with 5-methoxy-N-(methylsulfonyl)-1H-indole-2-carboxamide=== | ||
| + | ==Function== | ||
| + | [[http://www.uniprot.org/uniprot/PANC_MYCTU PANC_MYCTU]] Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.<ref>PMID:11669627</ref> | ||
==About this Structure== | ==About this Structure== | ||
| - | + | [[3isj]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ISJ OCA]. | |
| + | |||
| + | ==See Also== | ||
| + | *[[Pantothenate synthetase|Pantothenate synthetase]] | ||
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID: | + | <ref group="xtra">PMID:019780086</ref><references group="xtra"/><references/> |
[[Category: Mycobacterium tuberculosis]] | [[Category: Mycobacterium tuberculosis]] | ||
[[Category: Pantoate--beta-alanine ligase]] | [[Category: Pantoate--beta-alanine ligase]] | ||
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[[Category: Wen, S.]] | [[Category: Wen, S.]] | ||
[[Category: Atp-binding]] | [[Category: Atp-binding]] | ||
| - | [[Category: Cytoplasm]] | ||
[[Category: Fragment-based drug design]] | [[Category: Fragment-based drug design]] | ||
[[Category: Ligase]] | [[Category: Ligase]] | ||
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[[Category: Pantothenate biosynthesis]] | [[Category: Pantothenate biosynthesis]] | ||
[[Category: Pantothenate synthetase]] | [[Category: Pantothenate synthetase]] | ||
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| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jan 28 14:48:08 2010'' | ||
Revision as of 09:27, 27 March 2013
Contents |
Crystal structure of pantothenate synthetase from Mycobacterium tuberculosis in complex with 5-methoxy-N-(methylsulfonyl)-1H-indole-2-carboxamide
Function
[PANC_MYCTU] Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.[1]
About this Structure
3isj is a 2 chain structure with sequence from Mycobacterium tuberculosis. Full crystallographic information is available from OCA.
See Also
Reference
- Hung AW, Silvestre HL, Wen S, Ciulli A, Blundell TL, Abell C. Application of fragment growing and fragment linking to the discovery of inhibitors of Mycobacterium tuberculosis pantothenate synthetase. Angew Chem Int Ed Engl. 2009;48(45):8452-6. PMID:19780086 doi:10.1002/anie.200903821
- ↑ Zheng R, Blanchard JS. Steady-state and pre-steady-state kinetic analysis of Mycobacterium tuberculosis pantothenate synthetase. Biochemistry. 2001 Oct 30;40(43):12904-12. PMID:11669627
Categories: Mycobacterium tuberculosis | Pantoate--beta-alanine ligase | Abell, C. | Blundell, T L. | Ciulli, A. | Hung, A W. | Silvestre, H L. | Wen, S. | Atp-binding | Fragment-based drug design | Ligase | Magnesium | Metal-binding | Nucleotide-binding | Pantothenate biosynthesis | Pantothenate synthetase
