3jsk
From Proteopedia
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{{STRUCTURE_3jsk| PDB=3jsk | SCENE= }} | {{STRUCTURE_3jsk| PDB=3jsk | SCENE= }} | ||
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===Thiazole synthase from Neurospora crassa=== | ===Thiazole synthase from Neurospora crassa=== | ||
| + | ==Function== | ||
| + | [[http://www.uniprot.org/uniprot/Q9HGR2_NEUCR Q9HGR2_NEUCR]] Involved in biosynthesis of the thiamine precursor thiazole. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylic acid (ADT), an adenylated thiazole intermediate. The reaction includes an iron-dependent sulfide transfer from a conserved cysteine residue of the protein to a thiazole intermediate. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme. May have additional roles in adaptation to various stress conditions and in DNA damage tolerance (By similarity).<ref>PMID:15544818</ref> | ||
==About this Structure== | ==About this Structure== | ||
| - | + | [[3jsk]] is a 16 chain structure with sequence from [http://en.wikipedia.org/wiki/Neurospora_crassa Neurospora crassa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JSK OCA]. | |
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| + | ==Reference== | ||
| + | <references group="xtra"/><references/> | ||
[[Category: Neurospora crassa]] | [[Category: Neurospora crassa]] | ||
[[Category: Bale, S.]] | [[Category: Bale, S.]] | ||
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[[Category: Biosynthetic protein]] | [[Category: Biosynthetic protein]] | ||
[[Category: Octameric thiazole synthase]] | [[Category: Octameric thiazole synthase]] | ||
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Revision as of 09:31, 27 March 2013
Contents |
Thiazole synthase from Neurospora crassa
Function
[Q9HGR2_NEUCR] Involved in biosynthesis of the thiamine precursor thiazole. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylic acid (ADT), an adenylated thiazole intermediate. The reaction includes an iron-dependent sulfide transfer from a conserved cysteine residue of the protein to a thiazole intermediate. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme. May have additional roles in adaptation to various stress conditions and in DNA damage tolerance (By similarity).[1]
About this Structure
3jsk is a 16 chain structure with sequence from Neurospora crassa. Full crystallographic information is available from OCA.
Reference
- ↑ Faou P, Tropschug M. Neurospora crassa CyPBP37: a cytosolic stress protein that is able to replace yeast Thi4p function in the synthesis of vitamin B1. J Mol Biol. 2004 Dec 3;344(4):1147-57. PMID:15544818 doi:10.1016/j.jmb.2004.09.097
