3iug
From Proteopedia
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===Crystal structure of the RhoGAP domain of RICS=== | ===Crystal structure of the RhoGAP domain of RICS=== | ||
| + | ==Function== | ||
| + | [[http://www.uniprot.org/uniprot/RICS_HUMAN RICS_HUMAN]] GTPase-activating protein (GAP) promoting GTP hydrolysis on RHOA, CDC42 and RAC1 small GTPases. May be involved in the differentiation of neuronal cells during the formation of neurite extensions. Involved in NMDA receptor activity-dependent actin reorganization in dendritic spines. May mediate cross-talks between Ras- and Rho-regulated signaling pathways in cell growth regulation. Isoform 2 has higher GAP activity (By similarity).<ref>PMID:12446789</ref><ref>PMID:12819203</ref><ref>PMID:17663722</ref><ref>PMID:12788081</ref><ref>PMID:12454018</ref><ref>PMID:12531901</ref><ref>PMID:12857875</ref> | ||
==About this Structure== | ==About this Structure== | ||
| - | + | [[3iug]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IUG OCA]. | |
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| + | ==Reference== | ||
| + | <references group="xtra"/><references/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Arrowsmith, C H.]] | [[Category: Arrowsmith, C H.]] | ||
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[[Category: Tong, Y.]] | [[Category: Tong, Y.]] | ||
[[Category: Weigelt, J.]] | [[Category: Weigelt, J.]] | ||
| - | [[Category: Alternative splicing]] | ||
[[Category: Cell junction]] | [[Category: Cell junction]] | ||
[[Category: Cell membrane]] | [[Category: Cell membrane]] | ||
[[Category: Cell projection]] | [[Category: Cell projection]] | ||
| - | [[Category: Cytoplasm]] | ||
[[Category: Endoplasmic reticulum]] | [[Category: Endoplasmic reticulum]] | ||
[[Category: Endosome]] | [[Category: Endosome]] | ||
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[[Category: Postsynaptic cell membrane]] | [[Category: Postsynaptic cell membrane]] | ||
[[Category: Sh3 domain]] | [[Category: Sh3 domain]] | ||
| + | [[Category: Splicing]] | ||
[[Category: Synapse]] | [[Category: Synapse]] | ||
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| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 30 09:31:39 2009'' | ||
Revision as of 09:31, 27 March 2013
Contents |
Crystal structure of the RhoGAP domain of RICS
Function
[RICS_HUMAN] GTPase-activating protein (GAP) promoting GTP hydrolysis on RHOA, CDC42 and RAC1 small GTPases. May be involved in the differentiation of neuronal cells during the formation of neurite extensions. Involved in NMDA receptor activity-dependent actin reorganization in dendritic spines. May mediate cross-talks between Ras- and Rho-regulated signaling pathways in cell growth regulation. Isoform 2 has higher GAP activity (By similarity).[1][2][3][4][5][6][7]
About this Structure
3iug is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- ↑ Nakamura T, Komiya M, Sone K, Hirose E, Gotoh N, Morii H, Ohta Y, Mori N. Grit, a GTPase-activating protein for the Rho family, regulates neurite extension through association with the TrkA receptor and N-Shc and CrkL/Crk adapter molecules. Mol Cell Biol. 2002 Dec;22(24):8721-34. PMID:12446789
- ↑ Zhao C, Ma H, Bossy-Wetzel E, Lipton SA, Zhang Z, Feng GS. GC-GAP, a Rho family GTPase-activating protein that interacts with signaling adapters Gab1 and Gab2. J Biol Chem. 2003 Sep 5;278(36):34641-53. Epub 2003 Jun 19. PMID:12819203 doi:10.1074/jbc.M304594200
- ↑ Hayashi T, Okabe T, Nasu-Nishimura Y, Sakaue F, Ohwada S, Matsuura K, Akiyama T, Nakamura T. PX-RICS, a novel splicing variant of RICS, is a main isoform expressed during neural development. Genes Cells. 2007 Aug;12(8):929-39. PMID:17663722 doi:10.1111/j.1365-2443.2007.01101.x
- ↑ Taniguchi S, Liu H, Nakazawa T, Yokoyama K, Tezuka T, Yamamoto T. p250GAP, a neural RhoGAP protein, is associated with and phosphorylated by Fyn. Biochem Biophys Res Commun. 2003 Jun 20;306(1):151-5. PMID:12788081
- ↑ Moon SY, Zang H, Zheng Y. Characterization of a brain-specific Rho GTPase-activating protein, p200RhoGAP. J Biol Chem. 2003 Feb 7;278(6):4151-9. Epub 2002 Nov 25. PMID:12454018 doi:10.1074/jbc.M207789200
- ↑ Okabe T, Nakamura T, Nishimura YN, Kohu K, Ohwada S, Morishita Y, Akiyama T. RICS, a novel GTPase-activating protein for Cdc42 and Rac1, is involved in the beta-catenin-N-cadherin and N-methyl-D-aspartate receptor signaling. J Biol Chem. 2003 Mar 14;278(11):9920-7. Epub 2003 Jan 16. PMID:12531901 doi:10.1074/jbc.M208872200
- ↑ Nakazawa T, Watabe AM, Tezuka T, Yoshida Y, Yokoyama K, Umemori H, Inoue A, Okabe S, Manabe T, Yamamoto T. p250GAP, a novel brain-enriched GTPase-activating protein for Rho family GTPases, is involved in the N-methyl-d-aspartate receptor signaling. Mol Biol Cell. 2003 Jul;14(7):2921-34. Epub 2003 Apr 4. PMID:12857875 doi:10.1091/mbc.E02-09-0623
Categories: Homo sapiens | Arrowsmith, C H. | Bochkarev, A. | Bountra, C. | Edwards, A M. | Li, Y. | Nedyalkova, L. | Park, H. | SGC, Structural Genomics Consortium. | Tempel, W. | Tong, Y. | Weigelt, J. | Cell junction | Cell membrane | Cell projection | Endoplasmic reticulum | Endosome | Gap | Golgi apparatus | Gtpase activation | Membrane | Phosphoprotein | Postsynaptic cell membrane | Sh3 domain | Splicing | Synapse
