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3jut

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[[Image:3jut.png|left|200px]]
 
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{{STRUCTURE_3jut| PDB=3jut | SCENE= }}
{{STRUCTURE_3jut| PDB=3jut | SCENE= }}
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===Acidic Fibroblast Growth Factor (FGF-1) complexed with gentisic acid===
===Acidic Fibroblast Growth Factor (FGF-1) complexed with gentisic acid===
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{{ABSTRACT_PUBMED_20145243}}
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==Function==
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[[http://www.uniprot.org/uniprot/FGF1_HUMAN FGF1_HUMAN]] Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro.<ref>PMID:8663044</ref><ref>PMID:16597617</ref><ref>PMID:20145243</ref>
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{{ABSTRACT_PUBMED_20145243}}
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==About this Structure==
==About this Structure==
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3JUT is a 6 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JUT OCA].
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[[3jut]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JUT OCA].
==Reference==
==Reference==
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<ref group="xtra">PMID:20145243</ref><references group="xtra"/>
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<ref group="xtra">PMID:020145243</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Fernandez, I S.]]
[[Category: Fernandez, I S.]]
[[Category: Gimenez-Gallego, G.]]
[[Category: Gimenez-Gallego, G.]]
[[Category: Romero, A.]]
[[Category: Romero, A.]]
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[[Category: Acetylation]]
 
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[[Category: Alternative splicing]]
 
[[Category: Angiogenesis]]
[[Category: Angiogenesis]]
[[Category: Developmental protein]]
[[Category: Developmental protein]]
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[[Category: Hormone]]
[[Category: Hormone]]
[[Category: Mitogen]]
[[Category: Mitogen]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 12 10:34:23 2010''
 

Revision as of 09:34, 27 March 2013

Template:STRUCTURE 3jut

Contents

Acidic Fibroblast Growth Factor (FGF-1) complexed with gentisic acid

Template:ABSTRACT PUBMED 20145243

Function

[FGF1_HUMAN] Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro.[1][2][3]

About this Structure

3jut is a 6 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Fernandez IS, Cuevas P, Angulo J, Lopez-Navajas P, Canales-Mayordomo A, Gonzalez-Corrochano R, Lozano RM, Valverde S, Jimenez-Barbero J, Romero A, Gimenez-Gallego G. Gentisic acid, a compound associated with plant defense and a metabolite of aspirin, heads a new class of in vivo fibroblast growth factor inhibitors. J Biol Chem. 2010 Apr 9;285(15):11714-29. Epub 2010 Feb 9. PMID:20145243 doi:10.1074/jbc.M109.064618
  1. ↑ Ornitz DM, Xu J, Colvin JS, McEwen DG, MacArthur CA, Coulier F, Gao G, Goldfarb M. Receptor specificity of the fibroblast growth factor family. J Biol Chem. 1996 Jun 21;271(25):15292-7. PMID:8663044
  2. ↑ Zhang X, Ibrahimi OA, Olsen SK, Umemori H, Mohammadi M, Ornitz DM. Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family. J Biol Chem. 2006 Jun 9;281(23):15694-700. Epub 2006 Apr 4. PMID:16597617 doi:10.1074/jbc.M601252200
  3. ↑ Fernandez IS, Cuevas P, Angulo J, Lopez-Navajas P, Canales-Mayordomo A, Gonzalez-Corrochano R, Lozano RM, Valverde S, Jimenez-Barbero J, Romero A, Gimenez-Gallego G. Gentisic acid, a compound associated with plant defense and a metabolite of aspirin, heads a new class of in vivo fibroblast growth factor inhibitors. J Biol Chem. 2010 Apr 9;285(15):11714-29. Epub 2010 Feb 9. PMID:20145243 doi:10.1074/jbc.M109.064618

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