3iv1
From Proteopedia
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{{STRUCTURE_3iv1| PDB=3iv1 | SCENE= }} | {{STRUCTURE_3iv1| PDB=3iv1 | SCENE= }} | ||
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===Coiled-coil domain of tumor susceptibility gene 101=== | ===Coiled-coil domain of tumor susceptibility gene 101=== | ||
| + | ==Function== | ||
| + | [[http://www.uniprot.org/uniprot/TS101_HUMAN TS101_HUMAN]] Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the association between the ESCRT-0 and ESCRT-I complex. Required for completion of cytokinesis; the function requires CEP55. May be involved in cell growth and differentiation. Acts as a negative growth regulator. Involved in the budding of many viruses through an interaction with viral proteins that contain a late-budding motif P-[ST]-A-P. This interaction is essential for viral particle budding of numerous retroviruses.<ref>PMID:11916981</ref><ref>PMID:17853893</ref><ref>PMID:17556548</ref> | ||
| - | == | + | ==About this Structure== |
| - | + | [[3iv1]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IV1 OCA]. | |
| - | == | + | ==Reference== |
| - | + | <references group="xtra"/><references/> | |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Arrowsmith, C H.]] | [[Category: Arrowsmith, C H.]] | ||
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[[Category: Wernimont, A K.]] | [[Category: Wernimont, A K.]] | ||
[[Category: Xue, S.]] | [[Category: Xue, S.]] | ||
| - | [[Category: Alternative splicing]] | ||
[[Category: Cell cycle]] | [[Category: Cell cycle]] | ||
[[Category: Cell division]] | [[Category: Cell division]] | ||
[[Category: Cell_cycle regulation]] | [[Category: Cell_cycle regulation]] | ||
| - | [[Category: Coiled coil]] | ||
[[Category: Coiled_coil]] | [[Category: Coiled_coil]] | ||
| - | [[Category: Cytoplasm]] | ||
[[Category: Endosome]] | [[Category: Endosome]] | ||
[[Category: Growth regulation]] | [[Category: Growth regulation]] | ||
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[[Category: Nucleus]] | [[Category: Nucleus]] | ||
[[Category: Phosphoprotein]] | [[Category: Phosphoprotein]] | ||
| - | [[Category: Polymorphism]] | ||
[[Category: Protein transport]] | [[Category: Protein transport]] | ||
[[Category: Sgc]] | [[Category: Sgc]] | ||
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[[Category: Transport]] | [[Category: Transport]] | ||
[[Category: Tumorigenesis]] | [[Category: Tumorigenesis]] | ||
| - | [[Category: Ubl conjugation]] | ||
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| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov 4 11:00:53 2009'' | ||
Revision as of 09:34, 27 March 2013
Contents |
Coiled-coil domain of tumor susceptibility gene 101
Function
[TS101_HUMAN] Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the association between the ESCRT-0 and ESCRT-I complex. Required for completion of cytokinesis; the function requires CEP55. May be involved in cell growth and differentiation. Acts as a negative growth regulator. Involved in the budding of many viruses through an interaction with viral proteins that contain a late-budding motif P-[ST]-A-P. This interaction is essential for viral particle budding of numerous retroviruses.[1][2][3]
About this Structure
3iv1 is a 8 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- ↑ Bishop N, Horman A, Woodman P. Mammalian class E vps proteins recognize ubiquitin and act in the removal of endosomal protein-ubiquitin conjugates. J Cell Biol. 2002 Apr 1;157(1):91-101. Epub 2002 Mar 26. PMID:11916981 doi:10.1083/jcb.200112080
- ↑ Morita E, Sandrin V, Chung HY, Morham SG, Gygi SP, Rodesch CK, Sundquist WI. Human ESCRT and ALIX proteins interact with proteins of the midbody and function in cytokinesis. EMBO J. 2007 Oct 3;26(19):4215-27. Epub 2007 Sep 13. PMID:17853893 doi:10.1038/sj.emboj.7601850
- ↑ Carlton JG, Martin-Serrano J. Parallels between cytokinesis and retroviral budding: a role for the ESCRT machinery. Science. 2007 Jun 29;316(5833):1908-12. Epub 2007 Jun 7. PMID:17556548 doi:10.1126/science.1143422
Categories: Homo sapiens | Arrowsmith, C H. | Avvakumov, G V. | Bochkarev, A. | Bountra, C. | Dhe-Paganon, S. | Edwards, A M. | Li, Y. | Neculai, D. | SGC, Structural Genomics Consortium. | Walker, J R. | Weigelt, J. | Wernimont, A K. | Xue, S. | Cell cycle | Cell division | Cell cycle regulation | Coiled coil | Endosome | Growth regulation | Host-virus interaction | Hydrolase | Membrane | Nucleus | Phosphoprotein | Protein transport | Sgc | Structural genomic | Structural genomics consortium | Transport | Tumorigenesis
