3ioc

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[[Image:3ioc.png|left|200px]]
 
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{{STRUCTURE_3ioc| PDB=3ioc | SCENE= }}
{{STRUCTURE_3ioc| PDB=3ioc | SCENE= }}
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===Crystal Structure of Mycobacterium Tuberculosis Pantothenate Synthetase at 2.50 Ang resolution in complex with 5'-deoxy-5'-(benzyldisulfanyl)-adenosine===
===Crystal Structure of Mycobacterium Tuberculosis Pantothenate Synthetase at 2.50 Ang resolution in complex with 5'-deoxy-5'-(benzyldisulfanyl)-adenosine===
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{{ABSTRACT_PUBMED_19827080}}
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==Function==
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[[http://www.uniprot.org/uniprot/PANC_MYCTU PANC_MYCTU]] Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.<ref>PMID:11669627</ref>
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{{ABSTRACT_PUBMED_19827080}}
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==About this Structure==
==About this Structure==
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3IOC is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IOC OCA].
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[[3ioc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IOC OCA].
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==See Also==
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*[[Pantothenate synthetase|Pantothenate synthetase]]
==Reference==
==Reference==
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<ref group="xtra">PMID:19827080</ref><references group="xtra"/>
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<ref group="xtra">PMID:019827080</ref><references group="xtra"/><references/>
[[Category: Mycobacterium tuberculosis]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Pantoate--beta-alanine ligase]]
[[Category: Pantoate--beta-alanine ligase]]
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[[Category: Scott, D E.]]
[[Category: Scott, D E.]]
[[Category: Atp-binding]]
[[Category: Atp-binding]]
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[[Category: Cytoplasm]]
 
[[Category: Drug design]]
[[Category: Drug design]]
[[Category: Dynamic combinatorial chemistry]]
[[Category: Dynamic combinatorial chemistry]]
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[[Category: Nucleotide-binding]]
[[Category: Nucleotide-binding]]
[[Category: Pantothenate biosynthesis]]
[[Category: Pantothenate biosynthesis]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jan 28 14:59:45 2010''
 

Revision as of 09:36, 27 March 2013

Template:STRUCTURE 3ioc

Contents

Crystal Structure of Mycobacterium Tuberculosis Pantothenate Synthetase at 2.50 Ang resolution in complex with 5'-deoxy-5'-(benzyldisulfanyl)-adenosine

Template:ABSTRACT PUBMED 19827080

Function

[PANC_MYCTU] Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.[1]

About this Structure

3ioc is a 2 chain structure with sequence from Mycobacterium tuberculosis. Full crystallographic information is available from OCA.

See Also

Reference

  • Scott DE, Dawes GJ, Ando M, Abell C, Ciulli A. A fragment-based approach to probing adenosine recognition sites by using dynamic combinatorial chemistry. Chembiochem. 2009 Nov 23;10(17):2772-9. PMID:19827080 doi:10.1002/cbic.200900537
  1. ↑ Zheng R, Blanchard JS. Steady-state and pre-steady-state kinetic analysis of Mycobacterium tuberculosis pantothenate synthetase. Biochemistry. 2001 Oct 30;40(43):12904-12. PMID:11669627

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