3dxu
From Proteopedia
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{{STRUCTURE_3dxu| PDB=3dxu | SCENE= }} | {{STRUCTURE_3dxu| PDB=3dxu | SCENE= }} | ||
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===The crystal structure of core JMJD2D complexed with FE and N-oxalylglycine=== | ===The crystal structure of core JMJD2D complexed with FE and N-oxalylglycine=== | ||
| + | ==Function== | ||
| + | [[http://www.uniprot.org/uniprot/KDM4D_HUMAN KDM4D_HUMAN]] Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Demethylates both di- and trimethylated H3 'Lys-9' residue, while it has no activity on monomethylated residues. Demethylation of Lys residue generates formaldehyde and succinate.<ref>PMID:16603238</ref> | ||
==About this Structure== | ==About this Structure== | ||
[[3dxu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DXU OCA]. | [[3dxu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DXU OCA]. | ||
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| + | ==Reference== | ||
| + | <references group="xtra"/><references/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Chen, Z.]] | [[Category: Chen, Z.]] | ||
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[[Category: Nucleus]] | [[Category: Nucleus]] | ||
[[Category: Oxidoreductase]] | [[Category: Oxidoreductase]] | ||
| - | [[Category: Polymorphism]] | ||
[[Category: Transcription]] | [[Category: Transcription]] | ||
[[Category: Transcription regulation]] | [[Category: Transcription regulation]] | ||
| - | [[Category: Zinc]] | ||
Revision as of 09:36, 27 March 2013
Contents |
The crystal structure of core JMJD2D complexed with FE and N-oxalylglycine
Function
[KDM4D_HUMAN] Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Demethylates both di- and trimethylated H3 'Lys-9' residue, while it has no activity on monomethylated residues. Demethylation of Lys residue generates formaldehyde and succinate.[1]
About this Structure
3dxu is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- ↑ Whetstine JR, Nottke A, Lan F, Huarte M, Smolikov S, Chen Z, Spooner E, Li E, Zhang G, Colaiacovo M, Shi Y. Reversal of histone lysine trimethylation by the JMJD2 family of histone demethylases. Cell. 2006 May 5;125(3):467-81. Epub 2006 Apr 6. PMID:16603238 doi:10.1016/j.cell.2006.03.028
Categories: Homo sapiens | Chen, Z. | Zhang, G. | Chromatin regulator | Dioxygenase | Histone demethylase | Iron | Jmjc | Jmjd2d | Metal-binding | Nog | Nucleus | Oxidoreductase | Transcription | Transcription regulation
