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3jua

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[[Image:3jua.jpg|left|200px]]
 
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{{STRUCTURE_3jua| PDB=3jua | SCENE= }}
{{STRUCTURE_3jua| PDB=3jua | SCENE= }}
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===Structural basis of YAP recognition by TEAD4 in the Hippo pathway===
===Structural basis of YAP recognition by TEAD4 in the Hippo pathway===
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{{ABSTRACT_PUBMED_20123908}}
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==Function==
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[[http://www.uniprot.org/uniprot/TEAD4_MOUSE TEAD4_MOUSE]] Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and non-cooperatively to the Sph and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription. Binds to the M-CAT motif (By similarity). Might play a role in the embryonic development of skeletal muscle.
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{{ABSTRACT_PUBMED_20123908}}
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==About this Structure==
==About this Structure==
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3JUA is a 8 chains structure with sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JUA OCA].
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[[3jua]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JUA OCA].
==Reference==
==Reference==
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<ref group="xtra">PMID:20123908</ref><references group="xtra"/>
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<ref group="xtra">PMID:020123908</ref><references group="xtra"/><references/>
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Chen, L.]]
[[Category: Chen, L.]]
[[Category: Song, H.]]
[[Category: Song, H.]]
[[Category: Activator]]
[[Category: Activator]]
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[[Category: Alternative splicing]]
 
[[Category: Dna-binding]]
[[Category: Dna-binding]]
[[Category: Hippo pathway]]
[[Category: Hippo pathway]]
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[[Category: Transcription regulation]]
[[Category: Transcription regulation]]
[[Category: Yap]]
[[Category: Yap]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 25 13:40:48 2010''
 

Revision as of 09:39, 27 March 2013

Template:STRUCTURE 3jua

Contents

Structural basis of YAP recognition by TEAD4 in the Hippo pathway

Template:ABSTRACT PUBMED 20123908

Function

[TEAD4_MOUSE] Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and non-cooperatively to the Sph and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription. Binds to the M-CAT motif (By similarity). Might play a role in the embryonic development of skeletal muscle.

About this Structure

3jua is a 8 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

  • Chen L, Chan SW, Zhang X, Walsh M, Lim CJ, Hong W, Song H. Structural basis of YAP recognition by TEAD4 in the hippo pathway. Genes Dev. 2010 Feb 1;24(3):290-300. PMID:20123908 doi:24/3/290

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