3jz7

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:3jz7.jpg|left|200px]]
 
- 
-
<!--
 
-
The line below this paragraph, containing "STRUCTURE_3jz7", creates the "Structure Box" on the page.
 
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
 
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
 
-
or leave the SCENE parameter empty for the default display.
 
-
-->
 
{{STRUCTURE_3jz7| PDB=3jz7 | SCENE= }}
{{STRUCTURE_3jz7| PDB=3jz7 | SCENE= }}
- 
===Crystal structure of the extracellular domains of coxsackie & adenovirus receptor from mouse (mCAR)===
===Crystal structure of the extracellular domains of coxsackie & adenovirus receptor from mouse (mCAR)===
 +
{{ABSTRACT_PUBMED_20181587}}
-
 
+
==Function==
-
<!--
+
[[http://www.uniprot.org/uniprot/CXAR_MOUSE CXAR_MOUSE]] Component of the epithelial apical junction complex that is essential for the tight junction integrity. Proposed to function as a homophilic cell adhesion molecule. Recruits MPDZ to intercellular contact sites. Probably involved in transepithelial migration of polymorphonuclear leukocytes (PMN) through adhesive interactions with AMICA1/JAML located in the plasma membrane of PMN (By similarity).<ref>PMID:9036860</ref><ref>PMID:9420240</ref><ref>PMID:10814828</ref> In vitro, acts as a receptor for group B coxsackieviruses and subgroup C of adenoviruses (AD2 and AD5).<ref>PMID:9036860</ref><ref>PMID:9420240</ref><ref>PMID:10814828</ref>
-
The line below this paragraph, {{ABSTRACT_PUBMED_20181587}}, adds the Publication Abstract to the page
+
-
(as it appears on PubMed at http://www.pubmed.gov), where 20181587 is the PubMed ID number.
+
-
-->
+
-
{{ABSTRACT_PUBMED_20181587}}
+
==About this Structure==
==About this Structure==
-
3JZ7 is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JZ7 OCA].
+
[[3jz7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JZ7 OCA].
==Reference==
==Reference==
-
<ref group="xtra">PMID:20181587</ref><references group="xtra"/>
+
<ref group="xtra">PMID:020181587</ref><references group="xtra"/><references/>
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Heinemann, U.]]
[[Category: Heinemann, U.]]
[[Category: Max, K E.A.]]
[[Category: Max, K E.A.]]
[[Category: Adenovirus]]
[[Category: Adenovirus]]
-
[[Category: Alternative splicing]]
 
[[Category: Cell adhesion]]
[[Category: Cell adhesion]]
[[Category: Cell adhesion molecule]]
[[Category: Cell adhesion molecule]]
Line 46: Line 32:
[[Category: Tight junction]]
[[Category: Tight junction]]
[[Category: Transmembrane]]
[[Category: Transmembrane]]
- 
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 17 09:30:38 2010''
 

Revision as of 09:39, 27 March 2013

Template:STRUCTURE 3jz7

Contents

Crystal structure of the extracellular domains of coxsackie & adenovirus receptor from mouse (mCAR)

Template:ABSTRACT PUBMED 20181587

Function

[CXAR_MOUSE] Component of the epithelial apical junction complex that is essential for the tight junction integrity. Proposed to function as a homophilic cell adhesion molecule. Recruits MPDZ to intercellular contact sites. Probably involved in transepithelial migration of polymorphonuclear leukocytes (PMN) through adhesive interactions with AMICA1/JAML located in the plasma membrane of PMN (By similarity).[1][2][3] In vitro, acts as a receptor for group B coxsackieviruses and subgroup C of adenoviruses (AD2 and AD5).[4][5][6]

About this Structure

3jz7 is a 1 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

  • Patzke C, Max KE, Behlke J, Schreiber J, Schmidt H, Dorner AA, Kroger S, Henning M, Otto A, Heinemann U, Rathjen FG. The coxsackievirus-adenovirus receptor reveals complex homophilic and heterophilic interactions on neural cells. J Neurosci. 2010 Feb 24;30(8):2897-910. PMID:20181587 doi:30/8/2897
  1. ↑ Bergelson JM, Cunningham JA, Droguett G, Kurt-Jones EA, Krithivas A, Hong JS, Horwitz MS, Crowell RL, Finberg RW. Isolation of a common receptor for Coxsackie B viruses and adenoviruses 2 and 5. Science. 1997 Feb 28;275(5304):1320-3. PMID:9036860
  2. ↑ Bergelson JM, Krithivas A, Celi L, Droguett G, Horwitz MS, Wickham T, Crowell RL, Finberg RW. The murine CAR homolog is a receptor for coxsackie B viruses and adenoviruses. J Virol. 1998 Jan;72(1):415-9. PMID:9420240
  3. ↑ Honda T, Saitoh H, Masuko M, Katagiri-Abe T, Tominaga K, Kozakai I, Kobayashi K, Kumanishi T, Watanabe YG, Odani S, Kuwano R. The coxsackievirus-adenovirus receptor protein as a cell adhesion molecule in the developing mouse brain. Brain Res Mol Brain Res. 2000 Apr 14;77(1):19-28. PMID:10814828
  4. ↑ Bergelson JM, Cunningham JA, Droguett G, Kurt-Jones EA, Krithivas A, Hong JS, Horwitz MS, Crowell RL, Finberg RW. Isolation of a common receptor for Coxsackie B viruses and adenoviruses 2 and 5. Science. 1997 Feb 28;275(5304):1320-3. PMID:9036860
  5. ↑ Bergelson JM, Krithivas A, Celi L, Droguett G, Horwitz MS, Wickham T, Crowell RL, Finberg RW. The murine CAR homolog is a receptor for coxsackie B viruses and adenoviruses. J Virol. 1998 Jan;72(1):415-9. PMID:9420240
  6. ↑ Honda T, Saitoh H, Masuko M, Katagiri-Abe T, Tominaga K, Kozakai I, Kobayashi K, Kumanishi T, Watanabe YG, Odani S, Kuwano R. The coxsackievirus-adenovirus receptor protein as a cell adhesion molecule in the developing mouse brain. Brain Res Mol Brain Res. 2000 Apr 14;77(1):19-28. PMID:10814828

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3jz7"
Personal tools