3iqq
From Proteopedia
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===X-ray structure of bovine TRTK12-Ca(2+)-S100B=== | ===X-ray structure of bovine TRTK12-Ca(2+)-S100B=== | ||
| + | {{ABSTRACT_PUBMED_20053360}} | ||
| - | + | ==Function== | |
| - | + | [[http://www.uniprot.org/uniprot/S100B_BOVIN S100B_BOVIN]] Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Could assist ATAD3A cytoplasmic processing, preventing aggregation and favoring mitochondrial localization (By similarity).<ref>PMID:14661952</ref> | |
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==About this Structure== | ==About this Structure== | ||
| - | + | [[3iqq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IQQ OCA]. | |
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID: | + | <ref group="xtra">PMID:020053360</ref><references group="xtra"/><references/> |
[[Category: Bos taurus]] | [[Category: Bos taurus]] | ||
[[Category: Charpentier, T H.]] | [[Category: Charpentier, T H.]] | ||
[[Category: Toth, E A.]] | [[Category: Toth, E A.]] | ||
[[Category: Weber, D J.]] | [[Category: Weber, D J.]] | ||
| - | [[Category: Acetylation]] | ||
[[Category: Alpha helical]] | [[Category: Alpha helical]] | ||
| - | [[Category: Calcium]] | ||
| - | [[Category: Cytoplasm]] | ||
[[Category: Ef hand]] | [[Category: Ef hand]] | ||
[[Category: Metal binding protein]] | [[Category: Metal binding protein]] | ||
[[Category: Metal-binding]] | [[Category: Metal-binding]] | ||
[[Category: Nucleus]] | [[Category: Nucleus]] | ||
| - | [[Category: Zinc]] | ||
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| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 10 15:16:06 2010'' | ||
Revision as of 09:40, 27 March 2013
Contents |
X-ray structure of bovine TRTK12-Ca(2+)-S100B
Template:ABSTRACT PUBMED 20053360
Function
[S100B_BOVIN] Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Could assist ATAD3A cytoplasmic processing, preventing aggregation and favoring mitochondrial localization (By similarity).[1]
About this Structure
3iqq is a 2 chain structure with sequence from Bos taurus. Full crystallographic information is available from OCA.
Reference
- Charpentier TH, Thompson LE, Liriano MA, Varney KM, Wilder PT, Pozharski E, Toth EA, Weber DJ. The effects of CapZ peptide (TRTK-12) binding to S100B-Ca2+ as examined by NMR and X-ray crystallography. J Mol Biol. 2010 Mar 12;396(5):1227-43. Epub 2010 Jan 4. PMID:20053360 doi:10.1016/j.jmb.2009.12.057
- ↑ Bhattacharya S, Large E, Heizmann CW, Hemmings B, Chazin WJ. Structure of the Ca2+/S100B/NDR kinase peptide complex: insights into S100 target specificity and activation of the kinase. Biochemistry. 2003 Dec 16;42(49):14416-26. PMID:14661952 doi:http://dx.doi.org/10.1021/bi035089a
