4ie2

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
'''Unreleased structure'''
+
{{STRUCTURE_4ie2| PDB=4ie2 | SCENE= }}
 +
===Crystal structure of human Arginase-2 complexed with inhibitor 1h===
 +
{{ABSTRACT_PUBMED_23453840}}
-
The entry 4ie2 is ON HOLD
+
==Function==
 +
[[http://www.uniprot.org/uniprot/ARGI2_HUMAN ARGI2_HUMAN]] May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to NO synthase. Since NO synthase is found in the penile corpus cavernosum smooth muscle, the clitoral corpus cavernosum and the vagina, arginase II plays a role in both male and female sexual arousal. It is therefore a potential target for the treatment of male and female sexual arousal disorders.
-
Authors: Cousido-Siah, A., Mitschler, A., Ruiz, F.X., Beckett ,P., Van Zandt, M.C., Ji, M.K., Whitehouse, D., Ryder, T., Jagdmann, E., Andreoli, M., Mazur, A., Padmanilayam, M., Schroeter, H., Golebiowski, A., Podjarny, A.
+
==About this Structure==
-
 
+
[[4ie2]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IE2 OCA].
-
Description: Crystal structure of human Arginase-2 complexed with inhibitor 1h
+
[[Category: Arginase]]
 +
[[Category: Homo sapiens]]
 +
[[Category: Andreoli, M.]]
 +
[[Category: Beckett ,P.]]
 +
[[Category: Cousido-Siah, A.]]
 +
[[Category: Golebiowski, A.]]
 +
[[Category: Jagdmann, E.]]
 +
[[Category: Ji, M K.]]
 +
[[Category: Mazur, A.]]
 +
[[Category: Mitschler, A.]]
 +
[[Category: Padmanilayam, M.]]
 +
[[Category: Podjarny, A.]]
 +
[[Category: Ruiz, F X.]]
 +
[[Category: Ryder, T.]]
 +
[[Category: Schroeter, H.]]
 +
[[Category: Whitehouse, D.]]
 +
[[Category: Zandt, M C.Van.]]
 +
[[Category: Alpha/beta fold]]
 +
[[Category: Arginine metabolism]]
 +
[[Category: Hydrolase]]
 +
[[Category: Hydrolase-hydrolase inhibitor complex]]
 +
[[Category: Manganese]]
 +
[[Category: Metalloenzyme]]
 +
[[Category: Mitochondrion]]

Revision as of 22:09, 3 April 2013

Template:STRUCTURE 4ie2

Crystal structure of human Arginase-2 complexed with inhibitor 1h

Template:ABSTRACT PUBMED 23453840

Function

[ARGI2_HUMAN] May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to NO synthase. Since NO synthase is found in the penile corpus cavernosum smooth muscle, the clitoral corpus cavernosum and the vagina, arginase II plays a role in both male and female sexual arousal. It is therefore a potential target for the treatment of male and female sexual arousal disorders.

About this Structure

4ie2 is a 3 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4ie2"
Personal tools