2xwc
From Proteopedia
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{{STRUCTURE_2xwc| PDB=2xwc | SCENE= }} | {{STRUCTURE_2xwc| PDB=2xwc | SCENE= }} | ||
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===Crystal structure of the DNA binding domain of human TP73 refined at 1.8 A resolution=== | ===Crystal structure of the DNA binding domain of human TP73 refined at 1.8 A resolution=== | ||
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{{ABSTRACT_PUBMED_22917970}} | {{ABSTRACT_PUBMED_22917970}} | ||
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| + | ==Function== | ||
| + | [[http://www.uniprot.org/uniprot/P73_HUMAN P73_HUMAN]] Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein.<ref>PMID:11753569</ref> <ref>PMID:10203277</ref> <ref>PMID:18174154</ref> | ||
==About this Structure== | ==About this Structure== | ||
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==See Also== | ==See Also== | ||
*[[P73|P73]] | *[[P73|P73]] | ||
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| + | ==Reference== | ||
| + | <references group="xtra"/><references/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Arrowsmith, C H.]] | [[Category: Arrowsmith, C H.]] | ||
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[[Category: Bullock, A N.]] | [[Category: Bullock, A N.]] | ||
[[Category: Canning, P.]] | [[Category: Canning, P.]] | ||
| - | [[Category: Delft, F | + | [[Category: Delft, F von.]] |
[[Category: Edwards, A M.]] | [[Category: Edwards, A M.]] | ||
[[Category: Krojer, T.]] | [[Category: Krojer, T.]] | ||
Revision as of 22:12, 3 April 2013
Contents |
Crystal structure of the DNA binding domain of human TP73 refined at 1.8 A resolution
Template:ABSTRACT PUBMED 22917970
Function
[P73_HUMAN] Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein.[1] [2] [3]
About this Structure
2xwc is a 1 chain structure with sequence from Homo sapiens. This structure supersedes the now removed PDB entry 2xip. Full crystallographic information is available from OCA.
See Also
Reference
- ↑ Grob TJ, Novak U, Maisse C, Barcaroli D, Luthi AU, Pirnia F, Hugli B, Graber HU, De Laurenzi V, Fey MF, Melino G, Tobler A. Human delta Np73 regulates a dominant negative feedback loop for TAp73 and p53. Cell Death Differ. 2001 Dec;8(12):1213-23. PMID:11753569 doi:10.1038/sj.cdd.4400962
- ↑ Kaelin WG Jr. The emerging p53 gene family. J Natl Cancer Inst. 1999 Apr 7;91(7):594-8. PMID:10203277
- ↑ Koida N, Ozaki T, Yamamoto H, Ono S, Koda T, Ando K, Okoshi R, Kamijo T, Omura K, Nakagawara A. Inhibitory role of Plk1 in the regulation of p73-dependent apoptosis through physical interaction and phosphorylation. J Biol Chem. 2008 Mar 28;283(13):8555-63. doi: 10.1074/jbc.M710608200. Epub 2008 , Jan 3. PMID:18174154 doi:10.1074/jbc.M710608200
