2lwa
From Proteopedia
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{{STRUCTURE_2lwa| PDB=2lwa | SCENE= }} | {{STRUCTURE_2lwa| PDB=2lwa | SCENE= }} | ||
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===Conformational ensemble for the G8A mutant of the influenza hemagglutinin fusion peptide=== | ===Conformational ensemble for the G8A mutant of the influenza hemagglutinin fusion peptide=== | ||
| + | {{ABSTRACT_PUBMED_23169643}} | ||
| - | + | ==Function== | |
| + | [[http://www.uniprot.org/uniprot/Q91IJ0_9INFA Q91IJ0_9INFA]] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore (By similarity).[RuleBase:RU003324][SAAS:SAAS013829_004_327643] | ||
==About this Structure== | ==About this Structure== | ||
Revision as of 22:51, 3 April 2013
Conformational ensemble for the G8A mutant of the influenza hemagglutinin fusion peptide
Template:ABSTRACT PUBMED 23169643
Function
[Q91IJ0_9INFA] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore (By similarity).[RuleBase:RU003324][SAAS:SAAS013829_004_327643]
About this Structure
2lwa is a 3 chain structure with sequence from Influenza a virus (a/hong kong/1035/1998(h1n1)). Full experimental information is available from OCA.
