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1an2

From Proteopedia

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[[Image:1an2.png|left|200px]]
 
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{{STRUCTURE_1an2| PDB=1an2 | SCENE= }}
{{STRUCTURE_1an2| PDB=1an2 | SCENE= }}
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===RECOGNITION BY MAX OF ITS COGNATE DNA THROUGH A DIMERIC B/HLH/Z DOMAIN===
===RECOGNITION BY MAX OF ITS COGNATE DNA THROUGH A DIMERIC B/HLH/Z DOMAIN===
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{{ABSTRACT_PUBMED_8479534}}
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{{ABSTRACT_PUBMED_8479534}}
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==Function==
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[[http://www.uniprot.org/uniprot/MAX_HUMAN MAX_HUMAN]] Transcription regulator. Forms a sequence-specific DNA-binding protein complex with MYC or MAD which recognizes the core sequence 5'-CAC[GA]TG-3'. The MYC-MAX complex is a transcriptional activator, whereas the MAD-MAX complex is a repressor. May repress transcription via the recruitment of a chromatin remodeling complex containing H3 'Lys-9' histone methyltransferase activity.
==About this Structure==
==About this Structure==
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==Reference==
==Reference==
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<ref group="xtra">PMID:008479534</ref><ref group="xtra">PMID:011258480</ref><ref group="xtra">PMID:017397256</ref><references group="xtra"/>
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<ref group="xtra">PMID:008479534</ref><ref group="xtra">PMID:011258480</ref><ref group="xtra">PMID:017397256</ref><references group="xtra"/><references/>
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Amare, A R.Ferre-D.]]
[[Category: Amare, A R.Ferre-D.]]

Revision as of 00:26, 4 April 2013

Template:STRUCTURE 1an2

Contents

RECOGNITION BY MAX OF ITS COGNATE DNA THROUGH A DIMERIC B/HLH/Z DOMAIN

Template:ABSTRACT PUBMED 8479534

Function

[MAX_HUMAN] Transcription regulator. Forms a sequence-specific DNA-binding protein complex with MYC or MAD which recognizes the core sequence 5'-CAC[GA]TG-3'. The MYC-MAX complex is a transcriptional activator, whereas the MAD-MAX complex is a repressor. May repress transcription via the recruitment of a chromatin remodeling complex containing H3 'Lys-9' histone methyltransferase activity.

About this Structure

1an2 is a 2 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

  • Ferre-D'Amare AR, Prendergast GC, Ziff EB, Burley SK. Recognition by Max of its cognate DNA through a dimeric b/HLH/Z domain. Nature. 1993 May 6;363(6424):38-45. PMID:8479534 doi:http://dx.doi.org/10.1038/363038a0
  • Cokol M, Nair R, Rost B. Finding nuclear localization signals. EMBO Rep. 2000 Nov;1(5):411-5. PMID:11258480 doi:10.1093/embo-reports/kvd092
  • Mahony S, Auron PE, Benos PV. DNA familial binding profiles made easy: comparison of various motif alignment and clustering strategies. PLoS Comput Biol. 2007 Mar 30;3(3):e61. Epub 2007 Feb 15. PMID:17397256 doi:10.1371/journal.pcbi.0030061

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OCA

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