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4hjp

From Proteopedia

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'''Unreleased structure'''
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{{STRUCTURE_4hjp| PDB=4hjp | SCENE= }}
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===SHP-1 catalytic domain WPD loop open===
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{{ABSTRACT_PUBMED_23514039}}
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The entry 4hjp is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/PTN6_HUMAN PTN6_HUMAN]] Modulates signaling by tyrosine phosphorylated cell surface receptors such as KIT and the EGF receptor/EGFR. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation. Plays a key role in hematopoiesis.<ref>PMID:11266449</ref>
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Authors: Alicea-Velazquez, N.L., Boggon, T.J.
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==About this Structure==
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[[4hjp]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HJP OCA].
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Description: OPEN
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Homo sapiens]]
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[[Category: Protein-tyrosine-phosphatase]]
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[[Category: Alicea-Velazquez, N L.]]
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[[Category: Boggon, T J.]]
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[[Category: Hydrolase]]
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[[Category: Phosphatase domain]]

Revision as of 01:31, 4 April 2013

Template:STRUCTURE 4hjp

Contents

SHP-1 catalytic domain WPD loop open

Template:ABSTRACT PUBMED 23514039

Function

[PTN6_HUMAN] Modulates signaling by tyrosine phosphorylated cell surface receptors such as KIT and the EGF receptor/EGFR. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation. Plays a key role in hematopoiesis.[1]

About this Structure

4hjp is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  1. ↑ Keilhack H, Muller M, Bohmer SA, Frank C, Weidner KM, Birchmeier W, Ligensa T, Berndt A, Kosmehl H, Gunther B, Muller T, Birchmeier C, Bohmer FD. Negative regulation of Ros receptor tyrosine kinase signaling. An epithelial function of the SH2 domain protein tyrosine phosphatase SHP-1. J Cell Biol. 2001 Jan 22;152(2):325-34. PMID:11266449

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