2m13

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'''Unreleased structure'''
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{{STRUCTURE_2m13| PDB=2m13 | SCENE= }}
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===The ZZ domain of cytoplasmic polyadenylation element binding protein 1 (CPEB1)===
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{{ABSTRACT_PUBMED_23500490}}
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The entry 2m13 is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/CPEB1_HUMAN CPEB1_HUMAN]] Sequence-specific RNA-binding protein that regulates mRNA cytoplasmic polyadenylation and translation initiation during oocyte maturation, early development and at postsynapse sites of neurons. Binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5'-UUUUUAU-3') within the mRNA 3'-UTR. In absence of phosphorylation and in association with TACC3 is also involved as a repressor of translation of CPE-containing mRNA; a repression that is relieved by phosphorylation or degradation (By similarity). Involved in the transport of CPE-containing mRNA to dendrites; those mRNAs may be transported to dendrites in a translationally dormant form and translationally activated at synapses (By similarity). Its interaction with APLP1 promotes local CPE-containing mRNA polyadenylation and translation activation (By similarity). Induces the assembly of stress granules in the absence of stress.<ref>PMID:15966895</ref> <ref>PMID:15731006</ref>
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Authors: Lee, B.M., Merkel, D.J., Wells, S.B., Hilburn, B.C., Elazzouzi, F., Perez-Alvarado, G.C.
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==About this Structure==
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[[2m13]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M13 OCA].
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Description: The ZZ domain of cytoplasmic polyadenylation element binding protein 1 (CPEB1)
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Homo sapiens]]
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[[Category: Elazzouzi, F.]]
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[[Category: Hilburn, B C.]]
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[[Category: Lee, B M.]]
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[[Category: Merkel, D J.]]
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[[Category: Perez-Alvarado, G C.]]
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[[Category: Wells, S B.]]
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[[Category: Metal binding protein]]
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[[Category: Zinc-binding protein]]
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[[Category: Zz motif]]

Revision as of 01:34, 4 April 2013

Template:STRUCTURE 2m13

Contents

The ZZ domain of cytoplasmic polyadenylation element binding protein 1 (CPEB1)

Template:ABSTRACT PUBMED 23500490

Function

[CPEB1_HUMAN] Sequence-specific RNA-binding protein that regulates mRNA cytoplasmic polyadenylation and translation initiation during oocyte maturation, early development and at postsynapse sites of neurons. Binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5'-UUUUUAU-3') within the mRNA 3'-UTR. In absence of phosphorylation and in association with TACC3 is also involved as a repressor of translation of CPE-containing mRNA; a repression that is relieved by phosphorylation or degradation (By similarity). Involved in the transport of CPE-containing mRNA to dendrites; those mRNAs may be transported to dendrites in a translationally dormant form and translationally activated at synapses (By similarity). Its interaction with APLP1 promotes local CPE-containing mRNA polyadenylation and translation activation (By similarity). Induces the assembly of stress granules in the absence of stress.[1] [2]

About this Structure

2m13 is a 1 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

  1. ↑ Sasayama T, Marumoto T, Kunitoku N, Zhang D, Tamaki N, Kohmura E, Saya H, Hirota T. Over-expression of Aurora-A targets cytoplasmic polyadenylation element binding protein and promotes mRNA polyadenylation of Cdk1 and cyclin B1. Genes Cells. 2005 Jul;10(7):627-38. PMID:15966895 doi:10.1111/j.1365-2443.2005.00870.x
  2. ↑ Wilczynska A, Aigueperse C, Kress M, Dautry F, Weil D. The translational regulator CPEB1 provides a link between dcp1 bodies and stress granules. J Cell Sci. 2005 Mar 1;118(Pt 5):981-92. PMID:15731006 doi:118/5/981

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