4g9z
From Proteopedia
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| - | + | {{STRUCTURE_4g9z| PDB=4g9z | SCENE= }} | |
| + | ===Lassa nucleoprotein with dsRNA reveals novel mechanism for immune suppression=== | ||
| - | The | + | ==Function== |
| + | [[http://www.uniprot.org/uniprot/NCAP_LASSJ NCAP_LASSJ]] Encapsidates the genome, protecting it from nucleases. The encapsidated genomic RNA is termed the nucleocapsid (NC). Serves as template for viral transcription and replication. The increased presence of protein N in host cell does not seem to trigger the switch from transcription to replication as observed in other negative strain RNA viruses. Disables the host innate defense by interfering with beta interferon (IFN-beta) production. Strongly inhibits the nuclear translocation of IRF3, a protein involved in IFN activation pathway. Also inhibits the activation of IFN-beta and IRF3-dependent promoters (By similarity). | ||
| - | + | ==About this Structure== | |
| - | + | [[4g9z]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Lassa_virus_josiah Lassa virus josiah]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G9Z OCA]. | |
| - | + | [[Category: Lassa virus josiah]] | |
| + | [[Category: Dong, C.]] | ||
| + | [[Category: Dong, H.]] | ||
| + | [[Category: Huang, Q.]] | ||
| + | [[Category: Jiang, X.]] | ||
| + | [[Category: Liang, Y.]] | ||
| + | [[Category: Ly, H.]] | ||
| + | [[Category: SSPF, Scottish Structural Proteomics Facility.]] | ||
| + | [[Category: Wang, W.]] | ||
| + | [[Category: 3'-5'-ribonuclease]] | ||
| + | [[Category: Nuclease]] | ||
| + | [[Category: Scottish structural proteomics facility]] | ||
| + | [[Category: Sspf]] | ||
| + | [[Category: Structural genomic]] | ||
| + | [[Category: Viral protein-rna complex]] | ||
Revision as of 01:48, 4 April 2013
Lassa nucleoprotein with dsRNA reveals novel mechanism for immune suppression
Function
[NCAP_LASSJ] Encapsidates the genome, protecting it from nucleases. The encapsidated genomic RNA is termed the nucleocapsid (NC). Serves as template for viral transcription and replication. The increased presence of protein N in host cell does not seem to trigger the switch from transcription to replication as observed in other negative strain RNA viruses. Disables the host innate defense by interfering with beta interferon (IFN-beta) production. Strongly inhibits the nuclear translocation of IRF3, a protein involved in IFN activation pathway. Also inhibits the activation of IFN-beta and IRF3-dependent promoters (By similarity).
About this Structure
4g9z is a 3 chain structure with sequence from Lassa virus josiah. Full crystallographic information is available from OCA.
