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4i9x

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'''Unreleased structure'''
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{{STRUCTURE_4i9x| PDB=4i9x | SCENE= }}
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===Crystal structure of human cytomegalovirus glycoprotein UL141 targeting the death receptor TRAIL-R2===
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The entry 4i9x is ON HOLD until Paper Publication
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==Disease==
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[[http://www.uniprot.org/uniprot/TR10B_HUMAN TR10B_HUMAN]] Defects in TNFRSF10B may be a cause of head and neck squamous cell carcinomas (HNSCC) [MIM:[http://omim.org/entry/275355 275355]]; also known as squamous cell carcinoma of the head and neck.
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Authors: Nemcovicova, I., Zajonc, D.M.
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==Function==
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[[http://www.uniprot.org/uniprot/TR10B_HUMAN TR10B_HUMAN]] Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis.<ref>PMID:15322075</ref>
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Description: Crystal structure of human cytomegalovirus glycoprotein UL141 targeting the death receptor TRAIL-R2
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==About this Structure==
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[[4i9x]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Human_herpesvirus_5_strain_merlin Human herpesvirus 5 strain merlin]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I9X OCA].
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Homo sapiens]]
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[[Category: Human herpesvirus 5 strain merlin]]
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[[Category: Nemcovicova, I.]]
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[[Category: Zajonc, D M.]]
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[[Category: Apoptosis]]
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[[Category: Ig-like domain]]

Revision as of 01:50, 4 April 2013

Template:STRUCTURE 4i9x

Contents

Crystal structure of human cytomegalovirus glycoprotein UL141 targeting the death receptor TRAIL-R2

Disease

[TR10B_HUMAN] Defects in TNFRSF10B may be a cause of head and neck squamous cell carcinomas (HNSCC) [MIM:275355]; also known as squamous cell carcinoma of the head and neck.

Function

[TR10B_HUMAN] Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis.[1]

About this Structure

4i9x is a 4 chain structure with sequence from Homo sapiens and Human herpesvirus 5 strain merlin. Full crystallographic information is available from OCA.

Reference

  1. ↑ Yamaguchi H, Wang HG. CHOP is involved in endoplasmic reticulum stress-induced apoptosis by enhancing DR5 expression in human carcinoma cells. J Biol Chem. 2004 Oct 29;279(44):45495-502. Epub 2004 Aug 18. PMID:15322075 doi:10.1074/jbc.M406933200

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OCA

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