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4ixh

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'''Unreleased structure'''
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{{STRUCTURE_4ixh| PDB=4ixh | SCENE= }}
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===Crystal Structure of the Catalytic Domain of the Inosine Monophosphate Dehydrogenase from Cryptosporidium parvum===
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The entry 4ixh is ON HOLD until sometime in the future
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==Function==
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[[http://www.uniprot.org/uniprot/IMDH_CRYPV IMDH_CRYPV]] Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity).<ref>PMID:15269207</ref>
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Authors: Kim, Y., Makowska-Grzyska, M., Gu, M., Kavitha, M., Hedstrom, L., Andesrson, W.F., Joachimiak, A., Center for Structural Genomics of Infectious Diseases (CSGID)
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==About this Structure==
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[[4ixh]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Cryptosporidium_parvum Cryptosporidium parvum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IXH OCA].
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Description: Crystal Structure of the Catalytic Domain of the Inosine Monophosphate Dehydrogenase from Cryptosporidium parvum
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Cryptosporidium parvum]]
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[[Category: IMP dehydrogenase]]
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[[Category: Andesrson, W F.]]
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[[Category: CSGID, Center for Structural Genomics of Infectious Diseases.]]
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[[Category: Gu, M.]]
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[[Category: Hedstrom, L.]]
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[[Category: Joachimiak, A.]]
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[[Category: Kavitha, M.]]
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[[Category: Kim, Y.]]
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[[Category: Makowska-Grzyska, M.]]
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[[Category: Alpha-beta fold]]
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[[Category: Center for structural genomics of infectious disease]]
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[[Category: Csgid]]
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[[Category: National institute of allergy and infectious disease]]
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[[Category: Niaid]]
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[[Category: Oxidoreductase]]
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[[Category: Structural genomic]]
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[[Category: Tim barrel]]

Revision as of 01:52, 4 April 2013

Template:STRUCTURE 4ixh

Contents

Crystal Structure of the Catalytic Domain of the Inosine Monophosphate Dehydrogenase from Cryptosporidium parvum

Function

[IMDH_CRYPV] Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity).[1]

About this Structure

4ixh is a 4 chain structure with sequence from Cryptosporidium parvum. Full crystallographic information is available from OCA.

Reference

  1. ↑ Umejiego NN, Li C, Riera T, Hedstrom L, Striepen B. Cryptosporidium parvum IMP dehydrogenase: identification of functional, structural, and dynamic properties that can be exploited for drug design. J Biol Chem. 2004 Sep 24;279(39):40320-7. Epub 2004 Jul 21. PMID:15269207 doi:10.1074/jbc.M407121200

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OCA

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