3krw
From Proteopedia
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{{STRUCTURE_3krw| PDB=3krw | SCENE= }} | {{STRUCTURE_3krw| PDB=3krw | SCENE= }} | ||
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===Human GRK2 in complex with Gbetgamma subunits and balanol (soak)=== | ===Human GRK2 in complex with Gbetgamma subunits and balanol (soak)=== | ||
| + | {{ABSTRACT_PUBMED_20128603}} | ||
| - | + | ==Function== | |
| - | + | [[http://www.uniprot.org/uniprot/ARBK1_HUMAN ARBK1_HUMAN]] Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner.<ref>PMID:19306925</ref> [[http://www.uniprot.org/uniprot/GBG2_BOVIN GBG2_BOVIN]] Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. [[http://www.uniprot.org/uniprot/GBB1_BOVIN GBB1_BOVIN]] Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. | |
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==About this Structure== | ==About this Structure== | ||
| - | + | [[3krw]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KRW OCA]. | |
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID: | + | <ref group="xtra">PMID:020128603</ref><references group="xtra"/><references/> |
[[Category: Bos taurus]] | [[Category: Bos taurus]] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Tesmer, J J.G.]] | [[Category: Tesmer, J J.G.]] | ||
[[Category: Tesmer, V M.]] | [[Category: Tesmer, V M.]] | ||
| - | [[Category: Acetylation]] | ||
[[Category: Atp-binding]] | [[Category: Atp-binding]] | ||
[[Category: Cell membrane]] | [[Category: Cell membrane]] | ||
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[[Category: Ph domain]] | [[Category: Ph domain]] | ||
[[Category: Phosphoprotein]] | [[Category: Phosphoprotein]] | ||
| - | [[Category: Polymorphism]] | ||
[[Category: Prenylation]] | [[Category: Prenylation]] | ||
[[Category: Protein binding]] | [[Category: Protein binding]] | ||
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[[Category: Wd repeat]] | [[Category: Wd repeat]] | ||
[[Category: Wd40]] | [[Category: Wd40]] | ||
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| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 3 13:06:11 2010'' | ||
Revision as of 02:02, 4 April 2013
Contents |
Human GRK2 in complex with Gbetgamma subunits and balanol (soak)
Template:ABSTRACT PUBMED 20128603
Function
[ARBK1_HUMAN] Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner.[1] [GBG2_BOVIN] Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. [GBB1_BOVIN] Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
About this Structure
3krw is a 3 chain structure with sequence from Bos taurus and Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Tesmer JJ, Tesmer VM, Lodowski DT, Steinhagen H, Huber J. Structure of Human G Protein-Coupled Receptor Kinase 2 in Complex with the Kinase Inhibitor Balanol. J Med Chem. 2010 Feb 3. PMID:20128603 doi:10.1021/jm9017515
- ↑ Aziziyeh AI, Li TT, Pape C, Pampillo M, Chidiac P, Possmayer F, Babwah AV, Bhattacharya M. Dual regulation of lysophosphatidic acid (LPA1) receptor signalling by Ral and GRK. Cell Signal. 2009 Jul;21(7):1207-17. doi: 10.1016/j.cellsig.2009.03.011. Epub, 2009 Mar 21. PMID:19306925 doi:10.1016/j.cellsig.2009.03.011
Categories: Bos taurus | Homo sapiens | Tesmer, J J.G. | Tesmer, V M. | Atp-binding | Cell membrane | Complex | Inhibitor | Kinase | Lipoprotein | Membrane | Methylation | Nucleotide-binding | Ph domain | Phosphoprotein | Prenylation | Protein binding | Protein kinase | Rgs homology domain | Serine/threonine-protein kinase | Transducer | Transferase | Wd repeat | Wd40
